Diagonal earlobe crease and coronary artery disease in a Chinese population

BMC Cardiovascular Disorders

Research Article

Ming-lei Jin¹  Wen-hui Chai²  Ding-you Yang³  Xing-li Wu⁴  Yu-sheng Zhao⁴ 

[1] Department of Geriatrics, Chengde City People’s Hospital, Hebei, China;Department of Geriatrics, the Changji People’s Hospital, Urumqi, China;Department of Traditional Chinese Medicine, the First Affiliate Hospital of Chinese PLA General Hospital, Beijing, China;Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China;

关键词: Diagonal earlobe crease;    Coronary artery disease;    Chinese ethnics;    Coronary artery angiography;    Han Chinese;   

DOI  :  10.1186/1471-2261-14-43

 received in 2012-11-12, accepted in 2014-03-29,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMany reports have claimed associations between diagonal earlobe crease (DELC) and coronary artery disease (CAD), but data in Chinese populations are limited.MethodsThis cohort study investigated 449 consecutive Chinese, 250 cases with CAD and 199 without CAD, who were certified by coronary artery angiography in our center. Characteristic differences and the relation of DELC to CAD were assessed by Chi-square and t tests. The multivariate regression was performed to adjust for confounders and ROCs mode were used to detect its predicting performance for CAD.ResultsThe prevalence of DELC was 46.2% in those without CAD and 75.2% in those with CAD (P < .001). Subjects with DELC had more stenostic vessels and higher prevalence of both any and significant coronary artery stenosis than those without DELC (P < .001). The sensitivity, specificity and positive and negative predictive values for DELC to diagnose CAD in the whole population were 0.752, 0.538, 0.671 and 0.633. The higher sensitivity and positive predictive values (ppv) were found in male, the lowest sensitivity and the highest ppv in the <45 years old group, and the lowest specificity and ppv in the >75 years old group. After adjusting for other variables including age, gender and traditional risk factors, DELC remained a positive predictor for CAD (OR, 3.408; 95% CI 2.235-5.196; P < 0.001), but not for hypertension, diabetes mellitus, hypercholesterolemia and hypertriglyceridemia. ROC analysis showed the area under the curve was 0.645 (95% CI 0.593-0.697, p < 0.001).ConclusionsThe study showed a significant association between DELC and CAD independent of established risk factors in Chinese.

【 授权许可】

CC BY   
© Wu et al.; licensee BioMed Central Ltd. 2014