Noninvasive monitoring of cardiac function in a chronic ischemic heart failure model in the rat: Assessment with tissue Doppler and non-Doppler 2D strain echocardiography

Cardiovascular Ultrasound

Research

Fabian Knebel¹  Gert Baumann¹  Adrian C Borges¹  Sebastian Holinski²  Wolfgang Konertz²  Georg Heinze² 

[1] Department of Cardiology, Charité Campus Mitte, Schumannstr. 20/21, 10117, Berlin, Germany;Department of Cardiovascular Surgery, Charité Campus Mitte, Schumannstr. 20/21, 10117, Berlin, Germany;

关键词: Experimental Myocardial Infarction;    Regional Myocardial Function;    Regional Ventricular Function;    Regional Cardiac Function;    Chronic Ischemic Heart Failure;   

DOI  :  10.1186/1476-7120-9-15

 received in 2010-12-23, accepted in 2011-05-26,  发布年份 2011

来源: Springer

【 摘 要 】

ObjectivesFeasibility of noninvasive monitoring of cardiac function after surgically induced ischemic cardiomyopathy with tissue Doppler and non-Doppler 2D strain echocardiography in rats.BackgroundThe optimal method for quantitative assessment of global and regional ventricular function in rats with chronic heart failure for research purposes remains unclear.Methods20 rats underwent suture ligation of the left anterior descending coronary artery via a left thoracotomy to induce ischemic cardiomyopathy. Echocardiographic examination with estimation of left ventricular wall thickness, diameters, fractional shortening, ejection fraction, wall velocities as well as radial strain were performed before and 4 weeks after surgery.ResultsMean LVEF decreased from 70 ± 6% to 40 ± 8% (p < 0.0001) one month after the operation. LVEDD increased from 7 ± 1 mm to 9 ± 1 mm (p < 0.0001), systolic anterior velocity decreased from 0.79 ± 0.25 cm/s to 0.18 ± 0.19 cm/s (p < 0.0001). Radial 2D strain was significantly reduced after myocardial infarction of the septal (18.2 ± 6.6% vs 7.0 ± 5.9%, p < 0.001), anteroseptal (17.3 ± 5.2% vs 4.6 ± 3.0%, p < 0.0001), anterior (18.9 ± 5.9% vs 5.6 ± 2.5%, p < 0.0001), lateral (21.4 ± 4.9% vs 8.1 ± 3.5%, p < 0.0001) as well as posterior myocardial segments (19.3 ± 5.2% vs 15.4 ± 5.5%, p < 0.01). Inferior segments (19.2 ± 7.9% vs 17.8 ± 7.9%, ns) did not change at all.ConclusionIt is feasible to assess dimensions, global function, and regional contractility with echocardiography in rats suffering from chronic heart failure after myocardial infarction. Particularly regional function can be exactly evaluated if tissue Doppler and 2D strain is used.

【 授权许可】

CC BY   
© Holinski et al; licensee BioMed Central Ltd. 2011