Elevated high-sensitivity C-reactive protein levels increase the risk of new-onset cardiac conduction disorders

Cardiovascular Diabetology

Research

Shouling Wu¹  Shuohua Chen¹  Guodong Wang¹  Lili Wu²  Meimei Wu³  Yujing Wang⁴  Lina Xu⁴  Jiang Hong⁴  Lina An⁴  Dandan Zhao⁴  Congliang Miao⁴ 

[1] Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, No. 57 Xinhua East Road, 063001, Tangshan, China;Department of Cardiology, Shanghai Songjiang District Central Hospital, Shanghai, China;Division of Cardiovascular Diseases, Department of Emergency and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Hongkou District, 200080, Shanghai, China;Department of Emergency and Critical Care Medicine, Shanghai Songjiang District Central Hospital, Shanghai, China;Division of Cardiovascular Diseases, Department of Emergency and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Hongkou District, 200080, Shanghai, China;

关键词: Inflammation;    Conduction disorders;    High-sensitivity C-reactive protein;    Atrioventricular block;    Bundle branch block;   

DOI  :  10.1186/s12933-023-01987-1

 received in 2023-08-01, accepted in 2023-09-07,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPrevious studies have reported that inflammatory responses can promote the onset of cardiovascular diseases; however, its association with cardiac conduction disorders remains unclear. The present community-based cohort study aimed to elucidate the effects of inflammatory responses on the risk of developing cardiac conduction disorders.MethodsAfter the exclusion of participants failing to meet the inclusion criteria, 86,234 eligible participants (mean age: 50.57 ± 11.88 years) were included. The participants were divided into high-sensitivity C-reactive protein (hsCRP)  ≤  3 mg/L, and hsCRP > 3 mg/L groups based on hsCRP values. Multivariate Cox proportional hazard model was used to analyze the relationship between inflammatory responses and various cardiac conduction disorders.ResultsAfter adjusting for confounding factors, we observed that compared with the hsCRP ≤ 3 mg/L group, the hsCRP > 3 mg/L group exhibited increased risks of atrioventricular block (hazard ratio [HR]:1.64, 95%confidence interval [CI] 1.44–1.87) and left (HR:1.25, 95% CI 1.07–1.45) and right bundle branch block (HR:1.31, 95% CI 1.17–1.47). Moreover, the risk of various cardiac conduction disorders increased for every 1 standard deviation increase in log (hsCRP). The restricted cubic spline function confirmed a linear relationship between log (hsCRP) and the risk of developing cardiac conduction disorders (All nonlinearity P > 0.05).ConclusionsHigh hsCRP levels are an independent risk factor for cardiac conduction disorders, and hsCRP levels are dose-dependently associated with the risk of conduction disorders. Our study results may provide new strategies for preventing cardiac conduction disorders.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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