Prevalence, genetic diversity and antiretroviral drugs resistance-associated mutations among untreated HIV-1-infected pregnant women in Gabon, central Africa

BMC Infectious Diseases

Research Article

Guy-Patrick Obiang-Ndong¹  Olivia Biba¹  Mélanie Caron²  Sonia Etenna Lekana-Douki²  Maria Makuwa²  Mirdad Kazanji³  Dieudonné Nkoghé⁴ 

[1] Programme National de lutte contre le SIDA, BP 50, Libreville, Gabon;Unité de Rétrovirologie, Centre International de Recherches Médicales de Franceville, BP 769, Franceville, Gabon;Unité de Rétrovirologie, Centre International de Recherches Médicales de Franceville, BP 769, Franceville, Gabon;Institut Pasteur de Bangui, Réseau International des Instituts Pasteur, BP 923, Bangui, Central African Republic;Unité de Rétrovirologie, Centre International de Recherches Médicales de Franceville, BP 769, Franceville, Gabon;Ministère de la Santé, BP 5879, Libreville, Gabon;

关键词: HIV-1;    Prevalence;    Genetic diversity;    Resistance to antiretroviral drugs;    Untreated pregnant women;    Gabon;    Central Africa;   

DOI  :  10.1186/1471-2334-12-64

 received in 2011-11-30, accepted in 2012-03-20,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIn Africa, the wide genetic diversity of HIV has resulted in emergence of new strains, rapid spread of this virus in sub-Saharan populations and therefore spread of the HIV epidemic throughout the continent.MethodsTo determine the prevalence of antibodies to HIV among a high-risk population in Gabon, 1098 and 2916 samples were collected from pregnant women in 2005 and 2008, respectively. HIV genotypes were evaluated in 107 HIV-1-positive samples to determine the circulating subtypes of strains and their resistance to antiretroviral drugs (ARVs).ResultsThe seroprevalences were 6.3% in 2005 and 6.0% in 2008. The main subtype was recombinant CRF02_AG (46.7%), followed by the subtypes A (19.6%), G (10.3%), F (4.7%), H (1.9%) and D (0.9%) and the complex recombinants CRF06_cpx (1.9%) and CRF11_cpx (1.9%); 12.1% of subtypes could not be characterized. Analysis of ARVs resistance to the protease and reverse transcriptase coding regions showed mutations associated with extensive subtype polymorphism. In the present study, the HIV strains showed reduced susceptibility to ARVs (2.8%), particularly to protease inhibitors (1.9%) and nucleoside reverse transcriptase inhibitors (0.9%).ConclusionsThe evolving genetic diversity of HIV calls for continuous monitoring of its molecular epidemiology in Gabon and in other central African countries.

【 授权许可】

Unknown   
© Caron et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.