Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acids

Lipids in Health and Disease

Research

Yu J An¹  Fei F Yang²  Yong W Nie²  Xin F Liu²  Hong Guo²  Xiang B Ding²  Tao Guo³ 

[1] College of Animal Science, Inner Mongolia Agriculture University, 010018, Hohhot, China;Department of Animal Science, Tianjin Agriculture University, 300384, Tianjin, China;Department of Animal Science, Tianjin Agriculture University, 300384, Tianjin, China;College of Animal Science, Inner Mongolia Agriculture University, 010018, Hohhot, China;

关键词: fat-1;    transgenic cattle;    ω-3 fatty acids;    gene expression;    gene function;   

DOI  :  10.1186/1476-511X-10-244

 received in 2011-12-01, accepted in 2011-12-29,  发布年份 2011

来源: Springer

【 摘 要 】

ω-3 polyunsaturated fatty acids have been shown to play an important role in health. Enriched with ω-3 polyunsaturated fatty acids modulate expression of a number of genes with such broad functions as cell proliferation, growth and apoptosis and cell signaling and transduction, these effects, seem to regulate coronary artery disease, hypertension, atherosclerosis, psychiatric disorders and various cancer. In this context, fat-1 transgenic cattle was designed to convert ω-6 to ω-3 fatty acids could form an ideal model to study the effect of ω-3 fatty acids on the above functions. This study focuses on the total genomic difference of gene expression between fat-1 transgenic cattle and wild-type using cDNA microarrays, several genes were found to be overexpressed or suppressed in transgenic cattle relative to wild-type, these discrepancy genes related with lipid metabolism, immunity, inflammation nervous development and fertility.

【 授权许可】

CC BY   
© Guo et al; licensee BioMed Central Ltd. 2011