Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acids

Lipids in Health and Disease

Hong Guo¹  Yu J An²  Yong W Nie¹  Fei F Yang¹  Xiang B Ding¹  Xin F Liu¹  Tao Guo² 

[1] Department of Animal Science, Tianjin Agriculture University, Tianjin 300384, China;College of Animal Science, Inner Mongolia Agriculture University, Hohhot 010018, China

关键词: gene function;    gene expression;    ω-3 fatty acids;    transgenic cattle;    fat-1;   

Others  :  1212344
DOI  :  10.1186/1476-511X-10-244

 received in 2011-12-01, accepted in 2011-12-29,  发布年份 2011

【 摘 要 】

ω-3 polyunsaturated fatty acids have been shown to play an important role in health. Enriched with ω-3 polyunsaturated fatty acids modulate expression of a number of genes with such broad functions as cell proliferation, growth and apoptosis and cell signaling and transduction, these effects, seem to regulate coronary artery disease, hypertension, atherosclerosis, psychiatric disorders and various cancer. In this context, fat-1 transgenic cattle was designed to convert ω-6 to ω-3 fatty acids could form an ideal model to study the effect of ω-3 fatty acids on the above functions. This study focuses on the total genomic difference of gene expression between fat-1 transgenic cattle and wild-type using cDNA microarrays, several genes were found to be overexpressed or suppressed in transgenic cattle relative to wild-type, these discrepancy genes related with lipid metabolism, immunity, inflammation nervous development and fertility.

【 授权许可】

   
2011 Guo et al; licensee BioMed Central Ltd.

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