A case study on the potential angiogenic effect of human chorionic gonadotropin hormone in rapid progression and spontaneous regression of metastatic renal cell carcinoma during pregnancy and after surgical abortion

BMC Cancer

Case Report

Péter Göcze¹  Krisztina Bíró²  István Battyáni³  László Mangel⁴  Endre Kálmán⁵  Tamás Tornóczky⁵ 

[1] Clinic of Obstetrics and Gynecology, University of Pécs, Pécs, Hungary;Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary;Department of Radiology, University of Pécs, Pécs, Hungary;Institute of Oncotherapy, University of Pécs, H-7624, Édesanyák útja 17, Pécs, Hungary;Institute of Pathology, University of Pécs, Pécs, Hungary;

关键词: Human chorionic gonadotropin hormone;    Luteinizing hormone receptor;    Metastasis;    Pregnancy;    Renal cell carcinoma;   

DOI  :  10.1186/s12885-015-2031-1

 received in 2015-04-16, accepted in 2015-12-17,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundTreatment possibilities of metastatic renal cell carcinoma (mRCC) have recently changed dramatically prolonging the overall survival of the patients. This kind of development brings new challenges for the care of mRCC.Case presentationA 22 year-old female patient with translocation type mRCC, who previously had been treated for nearly 5 years, became pregnant during the treatment break period. Follow-up examinations revealed a dramatic clinical and radiological progression of mRCC in a few weeks therefore the pregnancy was terminated. A few days after surgical abortion, CT examination showed a significant spontaneous regression of the pulmonary metastases, and the volume of the largest manifestation decreased from ca. 30 to 3.5 cm3 in a week. To understand the possible mechanism of this spectacular regression, estrogen, progesterone and luteinizing hormone receptors (ER, PGR and LHR, respectively) immuno-histochemistry assays were performed on the original surgery samples. Immuno-histochemistry showed negative ER, PGR and positive LHR status suggesting the possible angiogenic effect of human chorionic gonadotropin hormone (hCG) in the background.ConclusionWe hypothesize that pregnancy may play a causal role in the progression of mRCC via the excess amount of hCG, however, more data are necessary to validate the present notions and the predictive role of LHR overexpression.

【 授权许可】

CC BY   
© Mangel et al. 2015