Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus

Cardiovascular Diabetology

Original Investigation

Chang Ho Ahn¹  Kyong Soo Park¹  Tae Jung Oh²  Sung Hee Choi²  Jae Hoon Moon²  Bo-Rahm Kim²  Soo Lim²  HakChul Jang²  Kyoung Min Kim²  Cheong Lim³ 

[1] Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea;Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea;Department of Internal Medicine, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, 463-070, Seongnam, South Korea;Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, South Korea;Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea;

关键词: Coronary artery disease;    Diabetes mellitus;    Sortilin;    Proneurotensin;    Biomarker;   

DOI  :  10.1186/s12933-017-0568-9

 received in 2017-03-17, accepted in 2017-06-22,  发布年份 2017

来源: Springer

【 摘 要 】

ContextA previous genome-wide association study showed that a genetic variant of sortilin was associated with the risk of coronary artery disease (CAD). However, the role of circulating sortilin is still unknown. We investigated the potential role of plasma sortilin as a biomarker for CAD and diabetes mellitus.MethodsWe enrolled statin-naïve subjects with CAD (n = 31) who underwent coronary artery bypass surgery and control subjects (n = 116) who were free from CAD as evaluated by coronary CT angiography. The presence of diabetes mellitus was evaluated and plasma sortilin levels were measured with a commercial ELISA kit.ResultsPlasma sortilin levels were higher in subjects with CAD and subjects with diabetes mellitus than in those without CAD or diabetes mellitus. Subjects in the highest sortilin tertile group were older and had higher glucose and HbA1c levels, but lipid profiles in the three tertile groups were comparable. Multivariable logistic regression analysis revealed that sortilin levels were independently associated with CAD. In addition, the receiver operating characteristic curve analysis showed that plasma sortilin levels could identify the presence of CAD or diabetes mellitus.ConclusionsElevated circulating sortilin levels are associated with CAD and diabetes mellitus and can be used as a biomarker of both diseases in statin-naïve subjects.

【 授权许可】

CC BY   
© The Author(s) 2017