Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels

Lipids in Health and Disease

Research

Abdelnaby Khalyfa¹  Jinkwan Kim¹  Mohamed Hegazi¹  Leila Kheirandish-Gozal¹  Bharat Bhushan¹  David Gozal¹  Rakesh Bhattacharjee²  Oscar Sans Capdevila³ 

[1] Department of Pediatrics, Comer Children's Hospital, The University of Chicago, Chicago, IL, USA;Division of Sleep and Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;Pediatric Sleep Unit, Division of Neurophysiology, Department of Neurology, Hospital Sant Joan de Déu, Barcelona, Spain;

关键词: Insulin Resistance;    Obese Child;    Fatty Acid Binding Protein;    hsCRP Level;    Adipocyte Fatty Acid Binding Protein;   

DOI  :  10.1186/1476-511X-9-18

 received in 2010-01-02, accepted in 2010-02-15,  发布年份 2010

来源: Springer

【 摘 要 】

IntroductionObesity increases the risk for insulin resistance and metabolic syndrome in both adults and children. FABP4 is a member of the intracellular lipid-binding protein family that is predominantly expressed in adipose tissue, and plays an important role in maintaining glucose and lipid homeostasis. The purpose of this study was to measure FABP4 plasma levels, assess FABP4 allelic variants, and explore potential associations with fasting glucose and insulin levels in young school-age children with and without obesity.MethodsA total of 309 consecutive children ages 5-7 years were recruited. Children were divided based on BMI z score into Obese (OB; BMI z score >1.65) and non-obese (NOB). Fasting plasma glucose, lipids, insulin, hsCRP, and FABP4 levels were measured. HOMA was used as correlate of insulin sensitivity. Four SNPs of the human FABP4 gene (rs1051231, rs2303519, rs16909233 and rs1054135), corresponding to several critical regions of the encoding FABP4 gene sequence were genotyped.ResultsCompared to NOB, circulating FABP4 levels were increased in OB, as were LDL, hsCRP and HOMA. FABP4 levels correlated with BMI, and also contributed to the variance of HOMA and hsCRP, but not serum lipids. The frequency of rs1054135 allelic variant was increased in OB, and was associated with increased FABP4 levels, while the presence of rs16909233 variant allele, although similar in OB and NOB, was associated with increased HOMA values.ConclusionsChildhood obesity is associated with higher FABP4 levels that may promote cardiometabolic risk. The presence of selective SNPs in the FABP4 gene may account for increased risk for insulin resistance or systemic inflammation in the context of obesity.

【 授权许可】

Unknown   
© Khalyfa et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.