Preoperative serum h-FABP concentration is associated with postoperative incidence of acute kidney injury in patients undergoing cardiac surgery

BMC Cardiovascular Disorders

Research Article

Christoph Schimmer¹  Mehmet Oezkur¹  Jennifer Peltz¹  Maria Lazariotou¹  Armin Gorski¹  Rainer G Leyh¹  Martin Wagner²  Peter U Heuschmann³ 

[1] Department of Cardiovascular Surgery, University Hospital Würzburg, Würzburg, Germany;Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany;Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany;Clinical Trial Center Würzburg, University Hospital Würzburg, Würzburg, Germany;

关键词: Acute Kidney Injury;    Fatty Acid Binding Protein;    Chronic Kidney Disease Stage;    Acute Kidney Injury Network;    Acute Kidney Injury Group;   

DOI  :  10.1186/1471-2261-14-117

 received in 2014-06-25, accepted in 2014-09-05,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundFatty acid binding protein (FABP) is an intracellular transport protein associated with myocardial damage size in patients undergoing cardiac surgery. Furthermore, elevated FABP serum concentrations are related to a number of common comorbidities, such as heart failure, chronic kidney disease, diabetes mellitus, and metabolic syndrome, which represent important risk factors for postoperative acute kidney injury (AKI). Data are lacking on the association between preoperative FABP serum level and postoperative incidence of AKI.MethodsThis prospective cohort study investigated the association between preoperative h-FABP serum concentrations and postoperative incidence of AKI, hospitalization time and length of ICU treatment. Blood samples were collected according to a predefined schedule. The AKI Network definition of AKI was used as primary endpoint. All associations were analysed using descriptive and univariate analyses.ResultsBetween 05/2009 and 09/2009, 70 patients undergoing cardiac surgery were investigated. AKI was observed in 45 patients (64%). Preoperative median (IQR) h-FABP differed between the AKI group (2.9 [1.7–4.1] ng/ml) and patients without AKI (1.7 [1.1–3.3] ng/ml; p = 0.04), respectively. Patients with AKI were significantly older. No statistically significant differences were found for gender, type of surgery, operation duration, CPB-, or X-Clamp time, preoperative cardiac enzymes, HbA1c, or CRP between the two groups. Preoperative h-FABP was also correlated with the length of ICU stay (rs = 0.32, p = 0.007).ConclusionsWe found a correlation between preoperative serum h-FABP and the postoperative incidence of AKI. Our results suggest a potential role for h-FABP as a biomarker for AKI in cardiac surgery.

【 授权许可】

CC BY   
© Oezkur et al.; licensee BioMed Central Ltd. 2014