Does a relationship still exist between gastroesophageal reflux and Helicobacter pylori in patients with reflux symptoms?

World Journal of Surgical Oncology

Research

Michela Campanelli¹  Giorgio Lisi¹  Giovanni Milito¹  Flavio De Sanctis¹  Alessia Esser¹  Valerio Balassone¹  Massimo Villa¹  Simona Grande¹  Michele Grande² 

[1] Department of Experimental Science and Surgery, Policlinico “Tor Vergata”, Viale Oxford, 81, 00133, Rome, Italy;Department of Experimental Science and Surgery, Policlinico “Tor Vergata”, Viale Oxford, 81, 00133, Rome, Italy;Department of Surgery, University Hospital Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy;

关键词: Helicobacter pylori;    RE;    GERD;    Esophageal manometry;    Endoscopic procedure;   

DOI  :  10.1186/1477-7819-12-375

 received in 2014-04-08, accepted in 2014-11-18,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe nature of the relationship between Helicobacter pylori and reflux esophagitis (RE) is not fully understood. In addition, the effect of H. pylori eradication on RE and gastroesophageal reflux disease (GERD) is unclear. This study was designed to investigate the relationship between H. pylori infection and the grade of GERD in patients with reflux symptoms.MethodsBetween January 2010 and July 2013, 184 consecutive patients with daily reflux symptoms for at least one year were evaluated at the ambulatory for functional esophageal disease, Tor Vergata University Hospital, Rome, Italy. All patients underwent a pretreatment evaluation, which included anamnesis, clinical examination, Esophagogastroduodenoscopy (EGDS) with biopsy, esophageal manometry and 24-hour pH-metry. All statistical elaborations were obtained using Statigraphies 5 plus for Window XP.ResultsThere was no statistical difference regarding Lower Esophageal Sphincter (LES) pressure between patients who were H. pylori-positive and H. Pylori-negative (19.2 ± 9.5 (range: 3.7 to 46.2) and 19.7 ± 11.0 (range: 2.6 to 61), respectively). Further, no significant difference was evidenced in esophageal wave length (mean value: 3.1 seconds in H. pylori-negative patients versus 3.2 seconds in H. pylori-positive patients) or in esophageal wave height (mean value: 72.2 ± 39.3 in H. pylori-negative patients versus 67.7 ± 28.4 in H. pylori-positive patients). We observed that hiatal hernia (P = 0.01), LES opening (P = 0.05), esophageal wave length (P = 0.01) and pathological reflux number (P = 0.05) were significantly related to the presence of esophagitis. However, H. pylori infection was not significantly related to the presence of reflux esophagitis.ConclusionsOur clinical, endoscopic, manometric and pH-metric data shows no significant role of H. pylori infection in the development of GERD or in the pathogenesis of reflux esophagitis. However, current data do not provide sufficient evidence to define this relationship and further prospective large studies are needed.

【 授权许可】

CC BY   
© Grande et al.; licensee BioMed Central. 2014