Genetic predisposition for femoral neck stress fractures in military conscripts

BMC Genetics

Research Article

Jürg Ott¹  Juha-Petri Ruohola²  Timo Sahi³  Svetlana Solovieva⁴  Harri Pihlajamäki⁵  Sandra Barral⁶  Minna Männikkö⁷  Johanna Korvala⁷  Heini Hartikka⁷  Leena Ala-Kokko⁸ 

[1] Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China;Centre for Military Medicine, Research Department, Helsinki, Finland;Centre for Military Medicine, Research Department, Helsinki, Finland;Department of Public Health, University of Helsinki, Helsinki, Finland;Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland;Department of Orthopaedic Surgery, National Military Hospital, Helsinki, Finland;Centre for Military Medicine, Research Department, Helsinki, Finland;Gertrude H. Sergievsky Center, College for Physicians and Surgeons, Columbia University, New York, USA;Oulu Center for Cell-Matrix Research, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland;Oulu Center for Cell-Matrix Research, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland;Connective Tissue Gene Tests, Allentown, PA, USA;

关键词: Bone Mineral Density;    Stress Fracture;    Femoral Neck Bone Mineral Density;    Military Conscript;    Femoral Neck Stress Fracture;   

DOI  :  10.1186/1471-2156-11-95

 received in 2010-06-08, accepted in 2010-10-21,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundStress fractures are a significant problem among athletes and soldiers and may result in devastating complications or even permanent handicap. Genetic factors may increase the risk, but no major susceptibility genes have been identified. The purpose of this study was to search for possible genetic factors predisposing military conscripts to femoral neck stress fractures.ResultsEight genes involved in bone metabolism or pathology (COL1A1, COL1A2, OPG, ESR1, VDR, CTR, LRP5, IL-6) were examined in 72 military conscripts with a femoral neck stress fracture and 120 controls. The risk of femoral neck stress fracture was significantly higher in subjects with low weight and body mass index (BMI). An interaction between the CTR (rs1801197) minor allele C and the VDR C-A haplotype was observed, and subjects lacking the C allele in CTR and/or the C-A haplotype in VDR had a 3-fold higher risk of stress fracture than subjects carrying both (OR = 3.22, 95% CI 1.38-7.49, p = 0.007). In addition, the LRP5 haplotype A-G-G-C alone and in combination with the VDR haplotype C-A was associated with stress fractures through reduced body weight and BMI.ConclusionsOur findings suggest that genetic factors play a role in the development of stress fractures in individuals subjected to heavy exercise and mechanical loading. The present results can be applied to the design of future studies that will further elucidate the genetics of stress fractures.

【 授权许可】

Unknown   
© Korvala et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.