Evaluation of RNA-binding motif protein 3 expression in urothelial carcinoma of the bladder: an immunohistochemical study

World Journal of Surgical Oncology

Research

Bin Xu¹  Fadi Brimo¹  Livia Florianova¹  Armen Aprikian²  Simon Tanguay²  Samer Traboulsi²  Hazem Elmansi²  Wassim Kassouf² 

[1] Department of Pathology, McGill University Health Centre and McGill University, Glen Site, 1001 Decarie Boulevard, H4A 3J1, Montreal, QC, Canada;Department of Urology, McGill University Health Centre and McGill University, Glen Site, 1001 Decarie Boulevard, H4A 3J1, Montreal, QC, Canada;

关键词: RBM3;    Expression;    Urothelial;    Carcinoma;    Prognosis;    Metastasis;   

DOI  :  10.1186/s12957-015-0730-3

 received in 2015-05-13, accepted in 2015-11-05,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundRNA-binding motif protein 3 (RBM3), involved in cell survival, has paradoxically been linked to both oncogenesis as well as an increased survival in several cancers, including urothelial carcinoma (UCA).MethodsThe putative prognostic role of RBM3 was studied using cystectomy specimens with 152 invasive UCA with 35 matched metastases, 65 carcinomas in situ (CIS), 22 high-grade papillary UCAs (PAP), and 112 benign urothelium cases.ResultsThe H-score (HS, staining intensity × % of positive cells) was used for RBM3 immunoexpression. CIS showed the highest HS (mean = 140) followed by benign urothelium (mean = 97). Metastases showed higher HS than primary invasive UCA (P ≤ 0.0001), and high HS was associated with a lower pT stage (P ≤ 0.0001) and a trend toward the absence of lymphovascular invasion (LVI, P = 0.09), but not pN stage (P = 0.35) and surgical margin status (P = 0.81). Univariate analysis (UVA) of disease recurrence only showed an association between pN stage and LVI (P = 0.005 and 0.03, respectively). On UVA of mortality, pT stage was strongly associated with death (P = 0.01) while pN stage, LVI, surgical margin status, and HS were not. Multivariate analysis confirmed the lack of HS association with recurrence (P = 0.08) and death (P = 0.32).ConclusionsStronger RBM3 immunoexpression correlated with lower stage tumors and a diminished risk for LVI. However, RBM3 does not seem to carry a prognostic significance for clinical outcome (recurrence and mortality). The exact prognostic role of RBM3 in UCA is yet to be determined.

【 授权许可】

CC BY   
© Florianova et al. 2015