Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis

BMC Cancer

Lisa Browning¹  Hayleigh Colling²  Richard Colling³  Clare Verrill⁴ 

[1]Department of Cellular Pathology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, OX3 9DU, Oxford, UK

[2]NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

[3]Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK

[4]Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK

[5]Department of Cellular Pathology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, OX3 9DU, Oxford, UK

[6]Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK

[7]Department of Cellular Pathology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, OX3 9DU, Oxford, UK

[8]NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

关键词: Bladder;    Urothelial;    Carcinoma;    Grade;    Digital pathology;   

DOI  :  10.1186/s12885-021-08698-4

来源: Springer

【 摘 要 】

BackgroundPathological grading of non-invasive urothelial carcinoma has a direct impact upon management. This study evaluates the reproducibility of grading these tumours on glass slides and digital pathology.MethodsForty eight non-invasive urothelial bladder carcinomas were graded by three uropathologists on glass and on a digital platform using the 1973 WHO and 2004 ISUP/WHO systems.ResultsConsensus grades for glass and digital grading gave Cohen’s kappa scores of 0.78 (2004) and 0.82 (1973). Of 142 decisions made on the key therapeutic borderline of low grade versus high grade urothelial carcinoma (2004) by the three pathologists, 85% were in agreement. For the 1973 grading system, agreement overall was 90%.ConclusionsAgreement on grading on glass slide and digital screen assessment is similar or in some cases improved, suggesting at least non-inferiority of DP for grading of non-invasive urothelial carcinoma.

【 授权许可】

CC BY