Responsiveness of the short-form health survey and the Parkinson’s disease questionnaire in patients with Parkinson’s disease

Health and Quality of Life Outcomes

Research

Wen-Juh Hwang¹  Shih-Pin Hsu²  Xiao-Jing Tu³  Hui-Ing Ma⁴ 

[1] Department of Neurology, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan;Department of Neurology, E-Da Hospital, I-Shou University, 1 Yida Road, Yanchao District, 82445, Kaohsiung, Taiwan;Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan;Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan;Department of Occupational Therapy, College of Medicine, National Cheng Kung University, 1 University Road, 70101, Tainan, Taiwan;

关键词: Health-related quality of life;    Parkinson’s disease;    PDQ-39;    SF-36;    Responsiveness;   

DOI  :  10.1186/s12955-017-0642-8

 received in 2016-06-17, accepted in 2017-03-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe responsiveness of a measurement instrument is important for understanding its ability to detect changes in the progression of a disease. We examined and compared the internal and external responsiveness of the 36-item Short-Form Health Survey (SF-36) and the 39-item Parkinson’s Disease Questionnaire (PDQ-39) in patients with Parkinson’s Disease (PD).MethodsSeventy-four patients with PD were evaluated using the SF-36 and PDQ-39 at baseline and again after one year. In addition, their motor signs, motor difficulties of daily living, and depressive symptoms were assessed as external criteria. The internal responsiveness was examined using effect size, standardized response mean, and the Wilcoxon signed rank test. The external responsiveness was examined using receiver operating characteristic curves, correlation analyses, and regression models.ResultsBoth instruments were partially sensitive to changes during the 1-year follow-up and able to discriminate between patients with improved versus deteriorated motor signs. In addition, both were similarly responsive to changes in the motor difficulties of daily living; the SF-36 appeared to be more sensitive than the PDQ-39 to changes in depressive symptoms.ConclusionsThe SF-36 and the PDQ-39 were acceptably internally and externally responsive during the 1-year follow-up.

【 授权许可】

CC BY   
© The Author(s). 2017