Prevalence of inflammatory bowel disease in two districts of Sri Lanka: a hospital based survey

BMC Gastroenterology

Research Article

A Rajitha Wickramasinghe¹  Asangi HGK Dayaratne¹  Madurangi HADP Ariyasinghe¹  D Nandadeva Samarasekara²  Ranjith SK Peiris³  Metthanandha MN Navarathne⁴  Raveendra L Satharasinghe⁵  Madunil A Niriella⁶  Anuradha S Dassanayake⁷  H Janaka de Silva⁷  Arjuna P De Silva⁷  Sharman Rajindrajith⁷ 

[1] Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka;Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka;Gastroenterology Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka;Gastroenterology Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka;Medical Unit, Sri Jayawardenapura General Hospital, Kotte, Sri Lanka;University Medical Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka;University Medical Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka;Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka;

关键词: Inflammatory Bowel Disease;    Ulcerative Colitis;    Inflammatory Bowel Disease Patient;    Ulcerative Colitis Patient;    Female Preponderance;   

DOI  :  10.1186/1471-230X-10-32

 received in 2009-08-04, accepted in 2010-03-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundInflammatory bowel disease (IBD) is being increasingly diagnosed in Asia. However there are few epidemiological data from the region.MethodsTo determine prevalence and clinical characteristics of IBD, a hospital-based survey was performed in the Colombo and Gampaha districts (combined population 4.5 million) in Sri Lanka. Patients with established ulcerative colitis (UC) and Crohn's disease (CD), who were permanent residents of these adjoining districts, were recruited from hospital registries and out-patient clinics. Clinical information was obtained from medical records and patient interviews.ResultsThere were 295 cases of IBD (UC = 240, CD = 55), of which 34 (UC = 30, CD = 4) were newly diagnosed during the study year. The prevalence rate for UC was 5.3/100,000 (95% CI 5.0-5.6/100,000), and CD was 1.2/100,000 (95% CI 1.0-1.4/100,000). The incidence rates were 0.69/100,000 (95% CI 0.44-0.94/100,000) for UC and 0.09/100,000 (95% CI 0.002-0.18/100,000) for CD. Female:male ratios were 1.5 for UC and 1.0 for CD. Mean age at diagnosis was (males and females) 36.6 and 38.1y for UC and 33.4 and 36.2y for CD. Among UC patients, 51.1% had proctitis and at presentation 58.4% had mild disease. 80% of CD patients had only large bowel involvement. Few patients had undergone surgery.ConclusionsThe prevalence of IBD in this population was low compared to Western populations, but similar to some in Asia. There was a female preponderance for UC. UC was mainly mild, distal or left-sided, while CD mainly involved the large bowel.

【 授权许可】

Unknown   
© Niriella et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.