Photon-counting detector CT-based virtual monoenergetic reconstructions: repeatability and reproducibility of radiomics features of an organic phantom and human myocardium

European Radiology Experimental

Original Article

Lukas Müller¹  Elias V. Wolf²  Tilman Emrich³  Moritz C. Halfmann⁴  Akos Varga-Szemes⁵  U. Joseph Schoepf⁵  Ismael M. Kabakus⁵  Joseph P. Griffith⁵  Dhiraj Baruah⁵  Pal Suranyi⁵  Nicola Fink⁶  Emese Zsarnoczay⁷  Jim O‘Doherty⁸ 

[1] Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany;Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany;Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA;Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany;Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA;German Centre for Cardiovascular Research, Partner site Rhine-Main, Mainz, Germany;Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany;German Centre for Cardiovascular Research, Partner site Rhine-Main, Mainz, Germany;Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA;Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA;Department of Radiology, University Hospital, LMU Munich, Munich, Germany;Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA;Medical Imaging Centre, Semmelweis University, Budapest, Hungary;Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA;Siemens Medical Solutions USA Inc, Malvern, PA, USA;

关键词: Myocardium;    Phantoms (imaging);    Radiomics;    Reproducibility of results;    Tomography (x-ray, computed);   

DOI  :  10.1186/s41747-023-00371-8

 received in 2023-05-12, accepted in 2023-07-17,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPhoton-counting detector computed tomography (PCD-CT) may influence imaging characteristics for various clinical conditions due to higher signal and contrast-to-noise ratio in virtual monoenergetic images (VMI). Radiomics analysis relies on quantification of image characteristics. We evaluated the impact of different VMI reconstructions on radiomic features in in vitro and in vivo PCD-CT datasets.MethodsAn organic phantom consisting of twelve samples (four oranges, four onions, and four apples) was scanned five times. Twenty-three patients who had undergone coronary computed tomography angiography on a first generation PCD-CT system with the same image acquisitions were analyzed. VMIs were reconstructed at 6 keV levels (40, 55, 70, 90, 120, and 190 keV). The phantoms and the patients’ left ventricular myocardium (LVM) were segmented for all reconstructions. Ninety-three original radiomic features were extracted. Repeatability and reproducibility were evaluated through intraclass correlations coefficient (ICC) and post hoc paired samples ANOVA t test.ResultsThere was excellent repeatability for radiomic features in phantom scans (all ICC = 1.00). Among all VMIs, 36/93 radiomic features (38.7%) in apples, 28/93 (30.1%) in oranges, and 33/93 (35.5%) in onions were not significantly different. For LVM, the percentage of stable features was high between VMIs ≥ 90 keV (90 versus 120 keV, 77.4%; 90 versus 190 keV, 83.9%; 120 versus 190 keV, 89.3%), while comparison to lower VMI levels led to fewer reproducible features (40 versus 55 keV, 8.6%).ConclusionsVMI levels influence the stability of radiomic features in an organic phantom and patients’ LVM; stability decreases considerably below 90 keV.Relevance statementSpectral reconstructions significantly influence radiomic features in vitro and in vivo, necessitating standardization and careful attention to these reconstruction parameters before clinical implementation.Key points• Radiomic features have an excellent repeatability within the same PCD-CT acquisition and reconstruction.• Differences in VMI lead to decreased reproducibility for radiomic features.• VMI ≥ 90 keV increased the reproducibility of the radiomic features.Graphical Abstract

【 授权许可】

CC BY   
© European Society of Radiology (ESR) 2023

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