Reproducibility of 2D versus 3D radiomics for quantitative assessment of fetal lung development: a retrospective fetal MRI study

Insights into Imaging

Original Article

Julian Rainer¹  Martin L. Watzenboeck¹  Victor Schmidbauer¹  Gregor Kasprian¹  Florian Prayer¹  Benedikt H. Heidinger¹  Barbara Ulm²  Erika Rubesova³  Daniela Prayer⁴ 

[1] Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria;Department of Obstetrics and Gynecology, Medical University of Vienna, Spitalgasse 23, Währinger Gürtel 18-20, 1090, Vienna, Austria;Department of Pediatric Radiology, Lucile Packard Children’s Hospital at Stanford, Stanford University, 725 Welch Road, 94305, Stanford, CA, USA;Imaging Bellaria, Bellariastrasse 3, 1010, Vienna, Austria;

关键词: Magnetic resonance imaging;    Fetal development;    Lung;    Reproducibility of results;    Radiomics;   

DOI  :  10.1186/s13244-023-01376-y

 received in 2022-09-05, accepted in 2023-01-16,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeTo investigate the reproducibility of radiomics features extracted from two-dimensional regions of interest (2D ROIs) versus whole lung (3D) ROIs in repeated in-vivo fetal magnetic resonance imaging (MRI) acquisitions.MethodsThirty fetal MRI scans including two axial T2-weighted acquisitions of the lungs were analysed. 2D (lung at the level of the carina) and 3D (whole lung) ROIs were manually segmented using ITK-Snap. Ninety-five radiomics features were extracted from 2 and 3D ROIs in initial and repeat acquisitions using Pyradiomics. Radiomics feature intra-class correlation coefficients (ICC) were calculated between 2 and 3D ROIs in the initial acquisition, and between 2 and 3D ROIs in repeated acquisitions, respectively.ResultsMRI data of 11 (36.7%) female and 19 (63.3%) male fetuses acquired at a median 25 + 0 gestational weeks plus days (GW) (interquartile range [IQR] 23 + 4 − 27 + 0 GW) were assessed. Median radiomics feature ICC between 2 and 3D ROIs in the initial MRI acquisition was 0.733 (IQR 0.313–0.814, range 0.018–0.970). ICCs between radiomics features extracted using 3D ROIs in initial and repeat acquisitions (median 0.908 [IQR 0.824–0.929, range 0.335–0.996]) were significantly higher compared to 2D ROIs (0.771 [0.699–0.835, 0.048–0.965]) (p < 0.001).ConclusionFetal MRI radiomics features extracted from 3D whole lung segmentation masks showed significantly higher reproducibility across repeat acquisitions compared to 2D ROIs. Therefore, fetal MRI whole lung radiomics features are robust diagnostic and potentially prognostic tools in the image-based in-vivo quantitative assessment of lung development.

【 授权许可】

CC BY   
© The Author(s) 2023

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