Hyperhomocysteinemia is associated with decreased apolipoprotein AI levels in normal healthy people

BMC Cardiovascular Disorders

Research Article

Heng Zhang¹  Jia Liu¹  Guang Wang¹  Yuliang Jiang¹  Song Leng²  Ying Wang³ 

[1]Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, NO. 8, Gongti South Road, Chaoyang District, 100020, Beijing, China

[2]Health Management Center, The Second Hospital of Dalian Medical University, NO. 467, Zhongshan Road, Shahekou District, 116000, Dalian, China

[3]Physical Examination Center, Beijing Chao-yang Hospital, Capital Medical University, NO. 8, Gongti South Road, Chaoyang district, 100020, Beijing, China

关键词: Hyperhomocysteinemia;    Apolipoprotein AI;    Cardiovascular disease;   

DOI  :  10.1186/s12872-016-0186-6

 received in 2015-09-28, accepted in 2016-01-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHyperhomocysteinemia (HHcy) is an independent risk factor for various cardiovascular diseases. Animal studies have shown that homocysteine (Hcy) inhibits hepatic expression of apolipoprotein AI (apoAI). Our recent clinical study showed that increased plasma Hcy levels were associated with decreased apoAI levels in patients with impaired glucose tolerance. In this study, we assessed a potential association between Hcy and apoAI levels in normal healthy people.MethodsA total of 1768 normal healthy individuals were divided into two groups: the control group (subjects without HHcy) and the HHcy group (subjects with HHcy).ResultsHHcy subjects exhibited significantly lower high-density lipoprotein cholesterol (HDL-C) and apoAI levels than the control group (HDL-C: 1.18 ± 0.25 vs. 1.29 ± 0.32 mmol/L; apoAI: 1.38 ± 0.19 vs. 1.47 ± 0.25 g/L; all P < 0.01). Plasma Hcy levels were negatively associated with HDL-C and apoAI levels after adjustments for age, BMI and TG (HDL-C: r = –0.10; apoAI: r = –0.11; all P < 0.05). Multivariate regression analysis showed that the plasma Hcy levels were an independent influencing factor for apoAI (β = –0.065, P < 0.05).ConclusionsIncreased plasma Hcy levels were associated with decreased apoAI levels in normal healthy people, and the inhibition of apoAI synthesis might be a mechanism through which Hcy is linked with the development of atherosclerosis in HHcy subjects.

【 授权许可】

CC BY   
© Wang et al. 2016