Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study

Population Health Metrics

Research

Barbara Suligoi¹  Vincenza Regine¹  Laura Camoni¹  Enrico Grande²  Francesco Grippo²  Marilena Pappagallo²  Luisa Frova²  Martina Taborelli³  Antonella Zucchetto³  Saverio Virdone³  Diego Serraino³ 

[1] Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy;Servizio Sistema integrato salute, assistenza, previdenza e giustizia, Istituto Nazionale di Statistica, Viale Liegi 13, 00198, Rome, Italy;Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Via Gallini 2, 33081, Aviano, PN, Italy;

关键词: HIV/AIDS;    Cause-specific mortality;    Multiple causes of death;    Italy;   

DOI  :  10.1186/s12963-017-0135-3

 received in 2016-06-16, accepted in 2017-05-04,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMultiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this study aimed to fully describe the cause-specific mortality of people with AIDS (PWA) compared to people without AIDS.MethodsWe conducted a nationwide investigation based on death certificates of 2,515 Italian PWA and 123,224 people without AIDS who had died between 2006 and 2010. The conditions most frequently associated with PWA mortality, compared to people without AIDS, were identified using an age-standardized proportion ratio (ASPR) calculated as the ratio between the age-standardized proportion of a specific cause among PWA and the same proportion among people without AIDS.ResultsThe most frequently reported conditions at death among PWA were infectious/parasitic diseases (52%), digestive (36%), respiratory (33%), and circulatory (32%) system diseases, and neoplasms (29%). All AIDS-defining conditions resulted highly associated (ASPR significantly greater than unity) with PWA deaths. Significant associations also emerged for leishmaniasis (ASPR = 188.0), encephalitis/myelitis/encephalomyelitis (ASPR = 14.3), dementia (ASPR = 13.1), chronic viral hepatitis (ASPR = 13.1), liver fibrosis/cirrhosis (ASPR = 4.4), pneumonia (ASPR = 4.4), anal (ASPR = 12.1) and liver (ASPR = 1.9) cancers, and Hodgkin’s disease (ASPR = 3.1).ConclusionsStudy findings identified the contribution of several non-AIDS-defining conditions on PWA mortality, emphasizing the need of preventive public health interventions targeting this population.

【 授权许可】

CC BY   
© The Author(s). 2017

【 图 表 】

Fig. 1: The conceptual framework for adherence to treatment guidelines in private drug outlets in Kisumu, Kenya

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