Analgesic and antibutyrylcholinestrasic activities of the venom prepared from the Mediterranean jellyfish Pelagia noctiluca (Forsskal, 1775)

Annals of Clinical Microbiology and Antimicrobials

Research

Hedi Ben Mansour¹  Afef Dellai¹  Yosra Ayed²  Salwa Abid²  Hassen Bacha³ 

[1] Laboratory for Biotechnology and Bio Geo Resources Valorisation (LBVBGR), High Institute of Biotechnology of Sidi Thabet University of Manouba, 2020, Ariana, Tunisia;Laboratory for Research on Biologically Compatible Compounds (LRSBC), Faculty of Dentistry, Monastir university, 5019, Rue Avicenne, Monastir, Tunisia;Laboratory for Research on Biologically Compatible Compounds (LRSBC), Faculty of Dentistry, Monastir university, 5019, Rue Avicenne, Monastir, Tunisia;University of Jendouba, Cité AlFaeiz rue Jamil Boutheina, 8100, Jendouba, Tunisia;

关键词: Pelagia noctiluca;    Venom;    Jellyfish;    Analgesic activity;    Anti-Butyrylcholinesterasic activity;   

DOI  :  10.1186/1476-0711-11-15

 received in 2011-12-19, accepted in 2012-05-13,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundToxins derived from jellyfishes have been exploited as a model for the development of new drug promising applications to treat neurodegenerative diseases. The present work is aimed to evaluate the acute toxicity of crude venom of Pelagia noctiluca and then to screen the analgesic and antibutyrylcholinestrasic (anti-BuChE) activities of the crude venom and its fractions.MethodsSephadex G75 gel was used to separate crude venom of Pelagia noctiluca, which led to some fractions. In addition, in vivo analgesic and in vitro plasma antibutyrylcholinestrasic activities were carried out with Pelagia crude venom and its fractions respectively.ResultsThe crude venom and its fractions displayed analgesic and anti-BuChE activities at different doses without inducing acute toxicity. Fraction 2 possesses the highest analgesic and antibutyrylcholinestrasic properties. The crude venom and fraction 1 had shown to possess less significant inhibitory activity against analgesic and antibutyrylcholinestrasic models.ConclusionsBased on this study, the crude venom of Pelagia noctiluca is found to be a useful tool for probing pharmacological activity. The purification and the determination of chemical structures of compounds of active fractions of the venom are under investigation.

【 授权许可】

Unknown   
© Ayed et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.