The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

BMC Cancer

Research Article

Kim Overvad¹  Esther Molina-Montes²  Rosario Tumino³  Carlotta Sacerdote⁴  Timothy J Key⁵  Ruth C Travis⁵  Núria Sala⁶  José Ramon Quirós⁷  Anne Tjønneland⁸  Jakob Stegger⁹  Salvatore Panico^1,10  Rudolf Kaaks^1,11  Birgit Teucher^1,11  Federico Canzian^1,11  Anika Hüsing^1,11  Sabine Rohrmann^1,11  Daniele Campa^1,11  Eva Fisher^1,12  Heiner Boeing^1,12  Erifili Oustoglou^1,13  Olga Sinilnikova^1,14  Elio Riboli^1,15  Afshan Siddiq^1,15  Guy Fagherazzi^1,16  Nathalie Chabbert-Buffet^1,16  Françoise Clavel-Chapelon^1,16  Eiliv Lund^1,17  Sabina Rinaldi^1,18  Nadia Slimani^1,18  James D McKay^1,18  Veronique Chajes^1,18  Vittorio Krogh^1,19  Carla H van Gils^2,20  N Charlotte Onland-Moret^2,20  Giovanna Masala^2,21  María Dolores Chirlaque^2,22  Ulla Vogel^2,23  H Bas Bueno-de-Mesquita^2,24  Pilar Amiano^2,25  Eva Ardanaz^2,26  Göran Hallmans^2,27  Per Lenner^2,27  Nick Wareham^2,28  Kay-Tee Khaw^2,28  Dimosthenis Zylis^2,29  Antonia Trichopoulou^3,30 

[1] Aarhus University Hospital, Aalborg, Denmark;Andalusian School of Public Health, Granada, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Spain;Azienda Ospedaliera "Civile M.P.Arezzo" Ragusa, Italy;CPO Piemonte, Turin, Italy;Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, OX3 7LF, Oxford, UK;Catalan Institute of Oncology, Barcelona, Spain;Consejería de Salud y Servicios Sanitarios Principado de Asturias, Oviedo, Spain;Danish Cancer Society, Copenhagen, Denmark;Department of Cardiology, Cardiovascular Research Centre, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark;Department of Clinical and Experimental Medicine Federico II University, Naples, Italy;German Cancer Research Center (DKFZ), Heidelberg, Germany;German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany;Hellenic Health Foundation, Athens, Greece;Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS-Université Claude Bernard, Lyon, France;Imperial College, London, UK;Institut Gustave Roussy, Villejuif, France;Institute of Community Medicine University of Tromsø, Tromsø, Norway;International Agency for Research on Cancer, Lyon, France;Istituto Nazionale dei Tumori (IRCCS), Milan, Italy;Julius Center, University Medical Center, Utrecht, The Netherlands;Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy;Murcia Regional Health Council, Murcia, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Spain;National Food Institute Technical University of Denmark, Denmark;National Institute for Public Health and the Environment, Bilthoven, The Netherlands;Public Health Department of Gipuzkoa, San Sebastian, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Spain;Public Health Institute of Navarra, Pamplona, Spain;Umeå University, Umeå, Sweden;University of Cambridge, Cambridge, UK;WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece;WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece;Hellenic Health Foundation, Athens, Greece;

关键词: Body Mass Index;    Breast Cancer;    Breast Cancer Risk;    Menopausal Status;    Unconditional Logistic Regression;   

DOI  :  10.1186/1471-2407-10-563

 received in 2010-01-20, accepted in 2010-10-18,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).Methodswe tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.Results and ConclusionsIn this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

【 授权许可】

Unknown   
© Campa et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.