Causes of changes in carotid intima-media thickness: a literature review

Cardiovascular Ultrasound

Review

Baoge Qu¹  Tao Qu² 

[1] Department of Gastroenterology, Taishan Hospital, 271000, Taian, Shandong, P. R. China;Zhuhai Campus of Zunyi Medical College, 519041, Zhuhai, Guangdong, P. R. China;

关键词: Ultrasound;    Atherosclerosis;    Peripheral vessel;    Carotid intima-media thickness;    Cardiovascular and cerebrovascular diseases;    Risk factors;   

DOI  :  10.1186/s12947-015-0041-4

 received in 2015-11-24, accepted in 2015-12-09,  发布年份 2015

来源: Springer

【 摘 要 】

Atherosclerosis causes significant morbidity and mortality. Carotid intima-media thickness (CIMT) predicts future cardiovascular and ischaemic stroke incidence. CIMT, a measure of atherosclerotic disease, can be reliably determined in vivo by carotid ultrasound. In this review, we determined that CIMT is associated with traditional cardiovascular risk factors such as age, sex, race, smoking, alcohol consumption, habitual endurance exercise, blood pressure, dyslipidemia, dietary patterns, risk-lowering drug therapy, glycemia, hyperuricemia, obesity-related anthropometric parameters, obesity and obesity-related diseases. We also found that CIMT is associated with novel risk factors, including heredity, certain genotypic indices, anthropometric cardiovascular parameters, rheumatoid arthritis, immunological diseases, inflammatory cytokines, lipid peroxidation, anthropometric hemocyte parameters, infectious diseases, vitamin D, matrix metalloproteinases, and other novel factors and diseases. However, the conclusions are inconsonant; the underlying causes of these associations remain to be further explored.

【 授权许可】

CC BY   
© Qu and Qu. 2015