Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer

BMC Cancer

Research Article

Jan Axtner¹  Harald Matthes²  Matthias Kröz²  Friedemann Schad²  Megan Steele³  Günther Spahn⁴ 

[1] Forschungsinstitut Havelhöhe gGmbH, Kladower Damm 221, 14089, Berlin, Germany;Forschungsinstitut Havelhöhe gGmbH, Kladower Damm 221, 14089, Berlin, Germany;Krankenhaus Havelhöhe, Kladower Damm 221, 14089, Berlin, Germany;Forschungsinstitut Havelhöhe gGmbH, Kladower Damm 221, 14089, Berlin, Germany;ihop Research Group, Queensland University of Technology, School of Public Health and Social Work, Victoria Park Road, 4059, Brisbane, Australia;Institut für Integrative Krebstherapie, Hans-Böckler-Str. 7, 55128, Mainz, Germany;

关键词: Pancreatic carcinoma;    Palliative care;    Integrative oncology;    Viscum album;    Mistletoe;   

DOI  :  10.1186/s12885-016-2594-5

 received in 2016-04-02, accepted in 2016-07-21,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPancreatic cancer has a dire prognosis and is associated with a high mortality. Palliative patients have special needs and often seek help in integrative oncological concepts (IO) that combine conventional and complementary therapies. Nevertheless there are few recommendations regarding IO in current cancer guidelines. The aims of this study were to report on implementation of IO in everyday palliative care and to analyze patient survival in advanced pancreatic cancer.MethodsThis multicenter observational study investigates the implementation of IO and length of survival of patients suffering from advanced pancreatic cancer (stage IV). We analyzed patient’s survival by employing multivariable proportional hazard models using different parametric distribution functions and compared patients receiving chemotherapy only, a combination of chemotherapy and Viscum album (VA) treatment, and VA treatment only.ResultsRecords of 240 patients were analyzed. Complementary therapy showed high acceptance (93 %). Most frequent therapy was VA treatment (74 %) that was often administered concomitantly to chemotherapy (64 %). Both therapies had positive effects on patient survival as they had significant negative effects on the hazard in our log-normal model. A second analysis showed that patients with combined chemotherapy and VA therapy performed significantly better than patients receiving only chemotherapy (12.1 to 7.3 month). Patients receiving only VA therapy showed longer survival than those receiving neither chemotherapy nor VA therapy (5.4 to 2.5 months). Our data demonstrates that IO can be implemented in the everyday care of patients without disregarding conventional treatment. Patients combining VA with chemotherapy showed longest survival.ConclusionsOur data demonstrate the importance and potential of health services research showing that IO treatment can be successfully implemented in the every-day care of patients suffering from advanced pancreatic cancer. Patients combining VA with chemotherapy showed longest survival. To address patients’ needs adequately, future cancer guidelines might increasingly include comments on complementary treatment options in addition to conventional therapies. Further studies should investigate the effect of complementary treatments on survival and quality of life in more detail.

【 授权许可】

CC BY   
© The Author(s). 2016