Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection

BMC Infectious Diseases

Case Report

Carlos Cedillo-Peláez¹  Gabriel Emmanuel Arce-Estrada¹  José Antonio Vargas-Villavicencio¹  Dolores Correa¹  Valeria Gómez-Toscano²  Ana Luisa Sesman-Bernal³  Vanessa Bosch-Canto⁴  José Luis Mayorga-Butrón⁵ 

[1] Laboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de Investigación, Av. Insurgentes Sur 3700-C, Col Insurgentes Cuicuilco, 04530, Ciudad de México, DF, Mexico;Laboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de Investigación, Av. Insurgentes Sur 3700-C, Col Insurgentes Cuicuilco, 04530, Ciudad de México, DF, Mexico;Servicio de Infectología, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Ciudad de México, Mexico;Servicio de Cirugía Plástica, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Ciudad de México, Mexico;Servicio de Oftalmología, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Ciudad de México, Mexico;Servicio de Otorrinolaringología, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Ciudad de México, Mexico;

关键词: Anophthalmia;    Congenital toxoplasmosis;    Craniofacial cleft;    Toxoplasma gondii;    Case report;   

DOI  :  10.1186/s12879-017-2565-8

 received in 2016-12-06, accepted in 2017-06-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWe present one unusual case of anophthalmia and craniofacial cleft, probably due to congenital toxoplasmosis only.Case presentationA two-month-old male had a twin in utero who disappeared between the 7th and the 14th week of gestation. At birth, the baby presented anophthalmia and craniofacial cleft, and no sign compatible with genetic or exposition/deficiency problems, like the Wolf-Hirschhorn syndrome or maternal vitamin A deficiency. Congenital toxoplasmosis was confirmed by the presence of IgM abs and IgG neo-antibodies in western blot, as well as by real time PCR in blood. CMV infection was also discarded by PCR and IgM negative results. Structures suggestive of T. gondii pseudocysts were observed in a biopsy taken during the first functional/esthetic surgery.ConclusionsWe conclude that this is a rare case of anophthalmia combined with craniofacial cleft due to congenital toxoplasmosis, that must be considered by physicians. This has not been reported before.

【 授权许可】

CC BY   
© The Author(s). 2017