Malaria in South America: a drug discovery perspective

Malaria Journal

Review

Marcus VG Lacerda¹  Timothy NC Wells²  Luiza R Cruz²  Thomas Spangenberg² 

[1] Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Av Pedro Teixeira, 25, 69040-000, Manaus, Amazonas, Brazil;Medicines for Malaria Venture, 20 route de Pré-Bois, CH 1215, Geneva, Switzerland;

关键词: South America;    Malaria;    Plasmodium;    Plasmodium vivax;    Treatment;    Resistance;    Drug discovery;    Review;   

DOI  :  10.1186/1475-2875-12-168

 received in 2013-03-05, accepted in 2013-05-15,  发布年份 2013

来源: Springer

【 摘 要 】

The challenge of controlling and eventually eradicating malaria means that new tools are urgently needed. South America’s role in this fight spans both ends of the research and development spectrum: both as a continent capable of discovering and developing new medicines, and also as a continent with significant numbers of malaria patients. This article reviews the contribution of groups in the South American continent to the research and development of new medicines over the last decade. Therefore, the current situation of research targeting malaria control and eradication is discussed, including endemicity, geographical distribution, treatment, drug-resistance and diagnosis. This sets the scene for a review of efforts within South America to discover and optimize compounds with anti-malarial activity.

【 授权许可】

CC BY   
© Cruz et al.; licensee BioMed Central Ltd. 2013