Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring

BMC Neuroscience

Research Article

Md. Mahbubur Rahman¹  Hasan Mahmud Reza¹  Rabeya Sultana¹  Sharmin Sultana¹  Md. Mamun Al-Amin² 

[1] Department of Pharmaceutical Sciences, North South University, Plot 15, Block B, Bashundhara, 1229, Dhaka, Bangladesh;Department of Pharmaceutical Sciences, North South University, Plot 15, Block B, Bashundhara, 1229, Dhaka, Bangladesh;The Queensland Brain Institute, The University of Queensland, St. Lucia, 4072, Brisbane, QLD, Australia;

关键词: Astaxanthin;    Lipopolysaccharide;    Depression;    Anxiety;    Oxidative stress;   

DOI  :  10.1186/s12868-016-0245-z

 received in 2015-08-23, accepted in 2016-01-28,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPrenatal maternal lipopolysaccharide (LPS) exposure leads to behavioral deficits such as depression, anxiety, and schizophrenia in the adult lives. LPS-exposure resulted in the production of cytokines and oxidative damage. On the contrary, astaxanthin is a carotenoid compound, showed neuroprotective properties via its antioxidant capacity. This study examines the effect of astaxanthin on the prenatal maternal LPS-induced postnatal behavioral deficit in mice.ResultsWe found that prenatal LPS-exposed mice showed extensive immobile phase in the tail suspension test, higher frequent head dipping in the hole-board test and greater hypolocomotion in the open field test. All these values were statistically significant (p < 0.05). In addition, a marked elevation of the level of lipid peroxidation, advanced protein oxidation product, nitric oxide, while a pronounced depletion of antioxidant enzymes (superoxide dismutase, catalase and glutathione) were observed in the adult offspring mice that were prenatally exposed to LPS. To the contrary, 6-weeks long treatment with astaxanthin significantly improved all behavioral deficits (p < 0.05) and diminished prenatal LPS-induced oxidative stress markers in the brain and liver.ConclusionsTaken together, these results suggest that prenatal maternal LPS-exposure leads to behavioral deficits in the adults, while astaxanthin ameliorates the behavioral deficits presumably via its antioxidant property.

【 授权许可】

CC BY   
© Al-Amin et al. 2016