Evaluation Of Antianxiety-Like Activity Of Astaxanthin And Its Possible Mechanism Of Action Using Animal Models.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

J Jayasheela¹  B Aravinda Kumar²  Isabella Topno²  Santhanalakshmi.¹ 

[1] Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences;Department of Pharmacology, Pondicherry Institute of Medical Sciences

关键词: Astaxanthin;    Anxiety;    Serotonin;    Diazepam;   

DOI  :  10.33887/rjpbcs/2021.12.1.5

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

The incidence of anxiety rapidly increasing among community. Present treatments have many sideeffects. Astaxanthin is a xanthophyll carotenoid which is found in various microorganisms and marine animals.It’s got antioxidant properties and neuroprotective effect. To evaluate the antianxiety-like activity of Astaxanthinand its possible mechanism of action using animal models namely elevated plus maze and hole board tests. Fifty-four healthy adult male swiss albino mice were used to study the acute and chronic antianxiety-like effect ofAstaxanthin (1, 3 and 5 mg/kg p.o.). After a washout period of 1 month, all the groups were used to study themechanism of action by blocking the Serotonergic and GABAergic system with the subsequent drugs namely p- Chlorophenylalanine (a serotonin synthesis inhibitor), pindolol (5HT1A/1B receptor antagonist), picrotoxin (a non- competitive GABA receptor antagonist) and flumazenil (a benzodiazepine site antagonist). The time spent withinthe open arm using elevated plus maze and the number of dipping’s and squares crossed within the hole boardtest was recorded as mean±SEM and analysed by one-way ANOVA test with post-hoc Bonferroni correction. Ourresults showed that Astaxanthin when administered acutely or chronically to mice (3, 5 mg/kg, p.o), produced asignificant anxiolytic effect (p<0.05) using both the behavioral models with a profile comparable to that ofdiazepam (1 mg/kg, p.o) mediated via serotonergic systems.

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