Comparison of zotarolimus-eluting and sirolimus-eluting coronary stents: a study from the Western Denmark Heart Registry

BMC Cardiovascular Disorders

Research Article

Hans-Henrik Tilsted¹  Evald Høj Christiansen²  Jens Flensted Lassen²  Michael Maeng²  Leif Thuesen²  Anne Kaltoft²  Per Thayssen³  Lisette Okkels Jensen³  Morten Madsen⁴  Henrik Toft Sørensen⁵ 

[1] Department of Cardiology, Aarhus University Hospital, Aalborg Hospital, Aalborg, Denmark;Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, 8200, Aarhus N, Denmark;Department of Cardiology, Odense University Hospital, Odense, Denmark;Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark;Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark;Department of Epidemiology, Boston University, Boston, MA, USA;

关键词: Zotarolimus;    Sirolimus;    Stent;    Mortality;    Stent thrombosis;    Diabetes mellitus;   

DOI  :  10.1186/1471-2261-12-84

 received in 2012-01-22, accepted in 2012-09-20,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundWe evaluated the effectiveness and safety of a zotarolimus-eluting (ZES) versus a sirolimus-eluting (SES) coronary stent in a large cohort of patients treated with one of these stents in Western Denmark.MethodsA total of 6,122 patients treated with ZES (n=2,282) or SES (n=3,840) were followed for up to 27 months. We ascertained clinical outcomes based on national medical databases.ResultsIncidence of target lesion revascularization (no. per 100 person-years) was 5.3 in the ZES group compared to 1.9 in the SES group (adjusted hazard ratio (HR)=2.19, 95% confidence intervals (CI): 1.39-3.47; p=0.001). All-cause mortality was also higher in the ZES group (ZES: 6.3; SES: 3.3; adjusted HR=1.34, 95% CI: 1.05-1.72; p=0.02), while stent thrombosis (ZES: 1.2; SES: 0.5; adjusted HR=1.98, 95% CI: 0.75-5.23; p=0.14) did not differ significantly.ConclusionsIn agreement with previously published randomised data, this observational study indicated that the ZES was associated with an increased risk of death and TLR in a large cohort of consecutive patients.

【 授权许可】

CC BY   
© Maeng et al.; licensee BioMed Central Ltd. 2012