Maternal blood manganese level and birth weight: a MOCEH birth cohort study

Environmental Health

Research

Namsoo Chang¹  Yangho Kim²  Mina Ha³  Eun-Hee Ha⁴  Hyesook Park⁴  Yun-Chul Hong⁵  Jin-Hee Eum⁶  Hae-Kwan Cheong⁶ 

[1] Department of Nutritional Science and Food Management, Ewha Womans University, 52 Ewhayeodae-gil, 120-750, Seodaemun-gu, Seoul, Republic of Korea;Department of Occupational and Environmental Medicine, University of Ulsan College of Medicine, 877 Bangeojinsunhwando-ro, 682-714, Dong-gu, Ulsan, Republic of Korea;Department of Preventive Medicine, Dankook University College of Medicine, 119 Dandae-ro, Dongnam-gu, 330-714, Cheonan, Chungnam, Republic of Korea;Department of Preventive Medicine, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, 158-710, Seoul, Republic of Korea;Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, 110-799, Jongno-gu, Seoul, Republic of Korea;Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, 2066 Seobu-ro, Jangan-gu, 440-746, Suwon, Gyeonggi-do, Republic of Korea;Department of Social and Preventive Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 135-990, Seoul, Republic of Korea;

关键词: In utero;    Birth outcome;    Birth cohort;    Foetal development;    Dose–response relationship;    Manganese;   

DOI  :  10.1186/1476-069X-13-31

 received in 2013-09-19, accepted in 2014-04-16,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundManganese (Mn) is an essential trace element for humans and animals, but excess intake of Mn can lead to adverse developmental outcome. Few studies have investigated the effects of deficiency or excess of Mn on the human foetus. In this study, we assessed the quantitative relationship between maternal blood Mn and birth weight of a newborn.MethodsWe performed analysis on 331 full-term, live birth singleton mother-infant pairs enrolled from July 2007 to December 2009 in the Mother and Children’s Environmental Health (MOCEH) study in Korea. A questionnaire on general characteristics, a review of medical records, and maternal whole blood Mn analysis were performed at full-term pregnancy. We evaluated the relationship between maternal blood level of Mn and the birth outcome using logistic regression and generalised additive model.ResultsThe mean Mn concentration in whole maternal blood was 22.5 μg/L. We found a curvilinear relationship between maternal blood Mn and birth weight after adjusting for potential confounders. Birth weight peaked at the maternal blood Mn level of 30 and 35 μg/L. An increased probability of birth weight below 3000 g was observed at both below 16.9 μg/L (odds ratio = 2.77, 95% CI: 0.89–8.65) and above 26.9 μg/L of maternal blood Mn level (odds ratio = 2.66, 95% CI: 0.84–8.08).ConclusionsOur study found that both extreme level of maternal Mn level was associated with lower birth weight outcome in a nonlinear fashion.

【 授权许可】

Unknown   
© Eum et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.