Prenatal exposure to lipopolysaccharide results in myocardial remodelling in adult murine offspring

Journal of Inflammation

Research

Dongfeng Chen¹  Wenhua Du²  Xiuqin Xiong²  Xiaohui Li³  Xiaoyan He³  Youcai Deng³  Yanling Wei⁴ 

[1] Department of Gastroenterology, Research Institute of Surgery, Da ping Hospital, The Third Military Medical University, Chongqing, China;Department of Ultrasound, Research Institute of Surgery, Da ping Hospital, The Third Military Medical University, Chongqing, China;The Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, The Third Military Medical University, Chongqing, China;The Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, The Third Military Medical University, Chongqing, China;Department of Gastroenterology, Research Institute of Surgery, Da ping Hospital, The Third Military Medical University, Chongqing, China;

关键词: Foetal development;    Maternal inflammation;    Myocardial remodelling;    Inhibitor of NF-κB;   

DOI  :  10.1186/1476-9255-10-35

 received in 2012-10-05, accepted in 2013-11-14,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe epigenetic plasticity hypothesis indicates that pregnancy exposure may result in adult-onset diseases, including hypertension, diabetes and cardiovascular disease, in offspring. In a previous study, we discovered that prenatal exposure to inflammatory stimulants, such as lipopolysaccharides (LPS), could lead to hypertension in adult rat offspring. In the present study, we further demonstrate that maternal inflammation induces cardiac hypertrophy and dysfunction via ectopic over-expression of nuclear transcription factor κB (NF- κB), and pyrrolidine dithiocarbamate (PDTC) can protect cardiac function by reducing maternal inflammation.MethodsPregnant SD rats were randomly divided into three groups and intraperitoneally injected with a vehicle, LPS (0.79 mg/kg), or LPS (0.79 mg/kg) plus PDTC (100 mg/kg) at 8 to 12 days of gestation. The offspring were raised until 4 and 8 months old, at which point an echocardiographic study was performed. The left ventricular (LV) mass index and apoptosis were examined.ResultsAt 4 months of age, the LPS offspring exhibited augmented posterior wall thickness. These rats displayed left ventricle (LV) hypertrophy and LV diastolic dysfunction as well as a higher apoptotic index, a higher level of Bax and a lower level of Bcl-2 at 8 months of age. The protein levels of NF-κB (p65) in the myocardium of the offspring were measured at this time. NF-κB protein levels were higher in the myocardium of LPS offspring. The offspring that were prenatally treated with PDTC displayed improved signs of blood pressure (BP) and LV hypertrophy.ConclusionsMaternal inflammation can induce cardiac hypertrophy in offspring during aging accompanied with hypertension emergence and can be rescued by the maternal administration of PDTC (the inhibitor of NF-κB).

【 授权许可】

Unknown   
© Wei et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.