Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content

Lipids in Health and Disease

Review

Yan-hong Li¹  Ling Liu¹ 

[1] Department of Cardiology, the Second Xiangya Hospital, Central South University, #139 Middle Renmin Road, 410011, Changsha, Hunan, PR China;

关键词: Apolipoprotein E;    Adipocyte;    Triglyceride;    Receptor-mediated endocytosis;   

DOI  :  10.1186/1476-511X-13-136

 received in 2014-05-18, accepted in 2014-08-18,  发布年份 2014

来源: Springer

【 摘 要 】

Excessive energy storage of adipose tissue makes contribution to the occurrence and progression of obesity, which accompanies with multiple adverse complications, such as metabolic syndrome, cardiovascular diseases. It is well known that apolipoprotein E, as a component of lipoproteins, performs a key role in maintaining plasma lipoproteins homeostasis. Interestingly, apolipoprotein E is highly expressed in adipocyte and has positive relation with body fat mass. Apolipoprotein E knock-out mice show small fat mass compared to wild type mice. Moreover, adipocyte deficiency in apolipoprotein E shows impaired lipoproeteins internalization and triglyceride accumulation. Apolipopreotein E-deficient lipoproteins can not induce preadipocyte to form round full-lipid adipocyte, whereas apolipoprotein E-containing lipoproteins can. This article mainly reviews the modulation of apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins in adipocyte triglyceride content.

【 授权许可】

CC BY   
© Li and Liu; licensee BioMed Central Ltd. 2014