Pharmacologic concentrations of linezolid modify oxidative phosphorylation function and adipocyte secretome

Redox Biology

Eduardo Ruiz-Pesini¹  Ester López-Gallardo¹  M. Pilar Bayona-Bafaluy¹  M. Ángeles Navarro¹  Laura Llobet¹  Julio Montoya¹  David Pacheu-Grau²  Elena Torres-Pérez³  José M. Arbones-Mainar³  Covadonga Gómez-Díaz⁴ 

[1] Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza, C/ Miguel Servet 177, 50013 Zaragoza, Spain;Department of Cellular Biochemistry, University Medical Center, Humboldtalle 23, 37073 Göttingen, Germany;Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Universidad de Zaragoza, C/ Miguel Servet 177, 50013 Zaragoza, Spain;Servicio de Otorrinolaringología, Hospital Universitario Miguel Servet, Paseo de Isabel la Católica 1-3, 50009 Zaragoza, Spain;

关键词: Linezolid;    Oxidative phosphorylation;    Adipocyte;    Secretome;    Apolipoprotein E;    Adipokine;   

DOI  :  10.1016/j.redox.2017.05.026

来源: DOAJ

【 摘 要 】

The oxidative phosphorylation system is important for adipocyte differentiation. Therefore, xenobiotics inhibitors of the oxidative phosphorylation system could affect adipocyte differentiation and adipokine secretion. As adipokines impact the overall health status, these xenobiotics may have wide effects on human health. Some of these xenobiotics are widely used therapeutic drugs, such as ribosomal antibiotics. Because of its similarity to the bacterial one, mitochondrial translation system is an off-target for these compounds. To study the influence of the ribosomal antibiotic linezolid on adipokine production, we analyzed its effects on adipocyte secretome. Linezolid, at therapeutic concentrations, modifies the levels of apolipoprotein E and several adipokines and proteins related with the extracellular matrix. This antibiotic also alters the global methylation status of human adipose tissue-derived stem cells and, therefore, its effects are not limited to the exposure period. Besides their consequences on other tissues, xenobiotics acting on the adipocyte oxidative phosphorylation system alter apolipoprotein E and adipokine production, secondarily contributing to their systemic effects.

【 授权许可】

Unknown