Insulin resistance is significantly associated with the metabolic syndrome, but not with sonographically proven peripheral arterial disease

Cardiovascular Diabetology

Original Investigation

Alexander Vonbank¹  Christoph H Saely¹  Philipp Rein¹  Heinz Drexel² 

[1] Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria;Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria;Private University of the Principality of Liechtenstein, Triesen, Liechtenstein;Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria;Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria;Private University of the Principality of Liechtenstein, Triesen, Liechtenstein;Drexel University College of Medicine, Philadelphia, PA, USA;

关键词: HOMA index;    Atherothrombosis;    Atherosclerosis;    Insulin;    Metabolic disorder;   

DOI  :  10.1186/1475-2840-12-106

 received in 2013-05-17, accepted in 2013-07-11,  发布年份 2013

来源: Springer

【 摘 要 】

ObjectiveInsulin resistance (IR) is the key feature of the metabolic syndrome (MetS); its association with peripheral arterial disease (PAD) is unclear. We hypothesized that IR is associated with both the MetS and sonographically proven PAD.MethodsIR was determined by the Homeostasis Model Assessment (HOMA) index in 214 patients with sonographically proven PAD as well as in 197 controls, who did not have a history of PAD and in whom coronary artery disease was ruled out angiographically; the MetS was defined according to NCEP-ATPIII criteria.ResultsHOMA IR scores were significantly higher in MetS patients than in subjects without the MetS (5.9 ± 6.2 vs. 2.9 ± 3.9; p <0.001). However, HOMA IR did not differ significantly between patients with PAD and controls (4.2 ± 5.4 vs. 3.3 ± 4.3; p = 0.124). When both, the presence of MetS and of PAD were considered, HOMA IR was significantly higher in patients with the MetS both among those with PAD (6.1 ± 5.7 vs. 3.6 ± 5.2; p<0.001) and among controls (5.8 ± 6.8 vs. 2.3 ± 1.8; p <0.001), whereas it did not differ significantly between patients with PAD and controls among patients with the MetS (5.8 ± 6.8 vs. 6.1 ± 5.7; p = 0.587) nor among those without the MetS (2.3 ± 1.8 vs. 3.6 ± 5.2; p = 0.165). Similar results were obtained with the International Diabetes Federation definition of the MetS.ConclusionIR is significantly associated with the MetS but not with sonographically proven PAD.

【 授权许可】

Unknown   
© Vonbank et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.