Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis

Lipids in Health and Disease

Research

Qin Xu¹  Yangxue Yin¹  Lingyun Liao¹  Shuangshuang Xie¹  Hongqin Chen¹  Rong Zhou¹ 

[1] Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of Education, No. 20, section 3, Renmin South Road, Wuhou District, 610041, Chengdu, Sichuan, China;NHC Key Laboratory of Chronobiology, Sichuan University, Chengdu, China;

关键词: Preeclampsia;    Chemerin;    Adipokine;    Systematic review;    Meta-analysis;   

DOI  :  10.1186/s12944-023-01941-w

 received in 2023-08-04, accepted in 2023-10-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPreeclampsia (PE) is a new-onset pregnancy-specific disorder with a high prevalence that leads to over 70 000 maternal and 500 000 foetal fatalities worldwide each year. The level of chemerin, a newly identified adipokine, is increased in diabetic and obese patients. Currently, there are several studies describing the relationship between maternal circulating chemerin levels and PE. Therefore, this study aimed to assess their association in pooled samples.MethodsFour databases were systematically searched to identify potential studies that reported circulating chemerin levels in PE and normal pregnancy groups. Standardized mean differences (SMDs), 95% confidence intervals (CIs), and 95% prediction intervals (PIs) were calculated using a random-effects meta-analysis. The probability of heterogeneity was also investigated by sensitivity analysis, subgroup analysis, and meta-regression.ResultsThirteen studies in 11 articles with a total of 860 PE patients and 1309 women with normal pregnancies met the inclusion criteria. The results of the meta-analysis revealed that circulating chemerin, which levels in PE patients were considerably higher than those in controls (SMD = 1.39, 95% CI: 1.02, 1.77, 95% PI: -0.07, 2.86). Moreover, sensitivity analysis determined that the outcomes of the overall pooled results were not affected after the elimination of any study. Notably, subgroup analysis demonstrated a similar expression pattern irrespective of geographic location, severity, timing of sampling, and sample size. Last, there were no factors that significantly impacted the overall estimate, according to meta-regression.ConclusionsThis meta-analysis is the first to assess circulating chemerin levels in PE patients. The findings indicate that circulating chemerin levels may be a potential marker to diagnose PE.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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