Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Research

Jürgen E Schneider¹  Emil KS Espe²  Ivar Sjaastad²  Lili Zhang²  Kristine Skårdal²  Jan Magnus Aronsen³ 

[1] Department of Cardiovascular Medicine, University of Oxford, Oxford, UK;Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Kirkeveien 166, N-0407, Oslo, Norway;KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway;Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Kirkeveien 166, N-0407, Oslo, Norway;KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway;Bjørknes College, Oslo, Norway;

关键词: CMR;    3D phase contrast;    Strain analysis;    Tissue phase mapping;    Myocardial motion;    Myocardial strain;    Motion artifacts;   

DOI  :  10.1186/1532-429X-15-82

 received in 2013-05-21, accepted in 2013-09-03,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPhase contrast velocimetry cardiovascular magnetic resonance (PC-CMR) is a powerful and versatile tool allowing assessment of in vivo motion of the myocardium. However, PC-CMR is sensitive to motion related artifacts causing errors that are geometrically systematic, rendering regional analysis of myocardial function challenging. The objective of this study was to establish an optimized PC-CMR method able to provide novel insight in the complex regional motion and strain of the rodent myocardium, and provide a proof-of-concept in normal and diseased rat hearts with higher temporal and spatial resolution than previously reported.MethodsA PC-CMR protocol optimized for assessing the motion and deformation of the myocardium in rats with high spatiotemporal resolution was established, and ten animals with different degree of cardiac dysfunction underwent examination and served as proof-of-concept. Global and regional myocardial velocities and circumferential strain were calculated, and the results were compared to five control animals. Furthermore, the global strain measurements were validated against speckle-tracking echocardiography, and inter- and intrastudy variability of the protocol were evaluated.ResultsThe presented method allows assessment of regional myocardial function in rats with high level of detail; temporal resolution was 3.2 ms, and analysis was done using 32 circumferential segments. In the dysfunctional hearts, global and regional function were distinctly altered, including reduced global peak values, increased regional heterogeneity and increased index of dyssynchrony. Strain derived from the PC-CMR data was in excellent agreement with echocardiography (r = 0.95, p < 0.001; limits-of-agreement −0.02 ± 3.92%strain), and intra- and interstudy variability were low for both velocity and strain (limits-of-agreement, radial motion: 0.01 ± 0.32 cm/s and −0.06 ± 0.75 cm/s; circumferential strain: -0.16 ± 0.89%strain and −0.71 ± 1.67%strain, for intra- and interstudy, respectively).ConclusionWe demonstrate, for the first time, that PC-CMR enables high-resolution evaluation of in vivo circumferential strain in addition to myocardial motion of the rat heart. In combination with the superior geometric robustness of CMR, this ultimately provides a tool for longitudinal studies of regional function in rodents with high level of detail.

【 授权许可】

CC BY   
© Espe et al.; licensee BioMed Central Ltd. 2013