The role of the insulin-like growth factor-1 system in breast cancer

Molecular Cancer

Review

Panagiotis F Christopoulos¹  Michael Koutsilieris¹  Pavlos Msaouel² 

[1] Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Goudi, Athens, Greece;Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA;

关键词: Insulin-like growth factor-1 (IGF-1);    IGF-1 receptor (IGF-1R);    IGF-binding proteins (IGFBPs);    IGF-1 signaling;    IGF-1 regulation;    Estrogens;    Estrogen receptor (ER);    Breast cancer;    Mammary tumorigenesis;   

DOI  :  10.1186/s12943-015-0291-7

 received in 2014-07-17, accepted in 2015-01-07,  发布年份 2015

来源: Springer

【 摘 要 】

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.

【 授权许可】

CC BY   
© Christopoulos et al.; licensee BioMed Central. 2015