Molecular Signatures of the Insulin-Like Growth Factor 1-Mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

International Journal of Molecular Sciences

Annamaria Mancini¹  Andreina Alfieri¹  Armando Cevenini²  Pasqualina Buono³  Stefania Orrù³  Esther Imperlini⁴ 

[1] CEINGE-Biotecnologie Avanzate S.c.a r.l., Via G. Salvatore 486, 80145 Napoli, Italy;Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, Via S. Pansini 5, 80131 Napoli, Italy;Dipartimento di Scienze Motorie e del Benessere, Università degli Studi di Napoli “Parthenope”, Via Medina 40, 80133 Napoli, Italy;IRCCS SDN, Via Francesco Crispi 8, 80121 Napoli, Italy;

关键词: insulin-like growth factor 1 (IGF-1);    IGF-1 receptor (IGF-1R);    epithelial-mesenchymal transition (EMT);    cancer;    metastasis;    PI3K/AKT pathway;    RAS/MEK/ERK pathway;   

DOI  :  10.3390/ijms19082411

来源: DOAJ

【 摘 要 】

The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2 peptide hormones, their corresponding receptors and several IGF binding proteins, is involved in physiological and pathophysiological processes. The IGF system promotes cancer proliferation/survival and its signaling induces the epithelial-mesenchymal transition (EMT) phenotype, which contributes to the migration, invasiveness, and metastasis of epithelial tumors. These cancers share two major IGF-1R signaling transduction pathways, PI3K/AKT and RAS/MEK/ERK. However, as far as we could review at this time, each type of cancer cell undergoes EMT through tumor-specific routes. Here, we review the tumor-specific molecular signatures of IGF-1-mediated EMT in breast, lung, and gastric cancers.

【 授权许可】

Unknown