Low fasting plasma insulin is associated with atrial fibrillation in men from a cohort study - the Malmö preventive project

BMC Cardiovascular Disorders

Research Article

Peter M Nilsson¹  Tord Juhlin¹  Linda SB Johnson¹  Gunnar Engström¹ 

[1] Department of Clinical Sciences, Lund University, Skåne University Hospital, Inga-Marie Nilssons väg 49, 20502, Malmö, Sweden;

关键词: Atrial fibrillation;    Fasting plasma insulin;    Hypertension;    Population;   

DOI  :  10.1186/1471-2261-14-107

 received in 2014-01-08, accepted in 2014-08-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundType 2 diabetes has been associated with increased incidence of atrial fibrillation (AF) and cardiovascular disease. Controversy remains regarding the role of insulin in the epidemiology of AF risk. The aim of the present study was to study the association between fasting plasma insulin (FPI) and incidence of AF, as well as any effect modification by fasting blood glucose (FBG) or 2 h post-load blood glucose and body mass index (BMI).MethodsThe study population consisted of 6052 men and 1014 women followed for an average of 26.2 years. There were 983 cases of incident AF. Analysis was performed using Cox regression and competing risks regression approaches. The population was analysed as a whole, and by subgroups according to glucose levels and BMI.ResultsAfter adjustment for age, height, weight, systolic blood pressure and smoking there was a significant inverse association between FPI and AF (hazard ratio; HR) for 4th vs. 1st quartile: 0.69 (95% confidence interval (CI): 0.57-0.83, p < 0.0001) in the cohort as a whole. Among men the corresponding values were HR 0.64 (95% CI 0.52-0.78, p < 0.001) and among women HR 1.16 (95% CI 0.69-1.93, p = 0.58); p-value for interaction 0.06. The protective effects of insulin tended to be weaker in subjects with elevated fasting glucose, implying that the relation between FPI and incident AF could be dependent on the status of individual’s glucose metabolism.ConclusionsHigh levels of FPI are associated with lower risk of incident AF in a middle-aged population with a long follow-up.

【 授权许可】

CC BY   
© Johnson et al.; licensee BioMed Central Ltd. 2014