A novel and practical cardiovascular magnetic resonance method to quantify mitral annular excursion and recoil applied to hypertrophic cardiomyopathy

Journal of Cardiovascular Magnetic Resonance

Research

Muhamed Saric¹  Stuart D Katz¹  Shahryar G Saba²  Robert Donnino³  Leon Axel³  Monvadi B Srichai⁴  Sohae Chung⁵  Sharath Bhagavatula⁵ 

[1] Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA;Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA;Current affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, 20892, Bethesda, MD, USA;Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA;Department of Radiology, Center for Biomedical Imaging, New York University Langone Medical Center, 660 First Avenue, Room 411, 10016, New York, NY, USA;Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA;Department of Radiology, Center for Biomedical Imaging, New York University Langone Medical Center, 660 First Avenue, Room 411, 10016, New York, NY, USA;Current affiliation: Medstar Heart Institute, Medstar Georgetown University Hospital, 20007, Washington, DC, USA;Department of Radiology, Center for Biomedical Imaging, New York University Langone Medical Center, 660 First Avenue, Room 411, 10016, New York, NY, USA;

关键词: Cardiovascular magnetic resonance;    Mitral annular motion;    Left ventricular function;    Hypertrophic cardiomyopathy;   

DOI  :  10.1186/1532-429X-16-35

 received in 2013-11-29, accepted in 2014-05-02,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundWe have developed a novel and practical cardiovascular magnetic resonance (CMR) technique to evaluate left ventricular (LV) mitral annular motion by tracking the atrioventricular junction (AVJ). To test AVJ motion analysis as a metric for LV function, we compared AVJ motion variables between patients with hypertrophic cardiomyopathy (HCM), a group with recognized systolic and diastolic dysfunction, and healthy volunteers.MethodsWe retrospectively evaluated 24 HCM patients with normal ejection fractions (EF) and 14 healthy volunteers. Using the 4-chamber view cine images, we tracked the longitudinal motion of the lateral and septal AVJ at 25 time points during the cardiac cycle. Based on AVJ displacement versus time, we calculated maximum AVJ displacement (MD) and velocity in early diastole (MVED), velocity in diastasis (VDS) and the composite index VDS/MVED.ResultsPatients with HCM showed significantly slower median lateral and septal AVJ recoil velocities during early diastole, but faster velocities in diastasis. We observed a 16-fold difference in VDS/MVED at the lateral AVJ [median 0.141, interquartile range (IQR) 0.073, 0.166 versus 0.009 IQR -0.006, 0.037, P < 0.001]. Patients with HCM also demonstrated significantly less mitral annular excursion at both the septal and lateral AVJ. Performed offline, AVJ motion analysis took approximately 10 minutes per subject.ConclusionsAtrioventricular junction motion analysis provides a practical and novel CMR method to assess mitral annular motion. In this proof of concept study we found highly statistically significant differences in mitral annular excursion and recoil between HCM patients and healthy volunteers.

【 授权许可】

Unknown   
© Saba et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.