Differences of left ventricular systolic deformation in hypertensive patients with and without apical hypertrophic cardiomyopathy

Cardiovascular Ultrasound

Research

Ming-Jui Hung¹  Wei-Siang Chen²  Ning-I Yang²  Yu-Cheng Kao²  Ming-Feng Lee²  Chun-Tai Mao²  Wen-Jin Cherng² 

[1] Department of Medicine, Chang Gung Memorial Hospital, Keelung, 222 Maijin Road, 20401, Keelung, Taiwan;Department of Medicine, Chang Gung Memorial Hospital, Keelung, 222 Maijin Road, 20401, Keelung, Taiwan;Chang Gung University College of Medicine, Taoyuan, Taiwan;

关键词: Hypertrophic cardiomyopathy;    Echocardiography;    Left ventricular function;   

DOI  :  10.1186/1476-7120-11-40

 received in 2013-08-03, accepted in 2013-11-09,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundWe tested the hypothesis that the apical myocardial mechanics differ from those of other ventricular segments in hypertensive patients with and without apical hypertrophic cardiomyopathy (ApHCM).MethodsWe retrospectively studied hypertensive patients with and without ApHCM. Left ventricular longitudinal, circumferential, and radial strains were examined by two-dimensional speckle-tracking echocardiography at the basal, middle, and apical walls of the parasternal short-axis and apical 2-, 3- and 4-chamber views.ResultsFourteen consecutive patients with hypertension and ApHCM and 14 patients with hypertension without ApHCM were studied. Lower mitral annular peak systolic velocity and greater diastolic dysfunction were present in hypertensive patients with ApHCM than in hypertensive patients without ApHCM. Compared with hypertensive patients without ApHCM, hypertensive patients with ApHCM had significantly lower apical longitudinal (−13.9% vs −21.9%, p = 0.010) and radial strains (4.4% vs 11.5%, p = 0.017) without the base-to-apex gradient. The global longitudinal (−15.6% vs −18.8%, p = 0.027) and circumferential strains (−16.1% vs −19.2%, p = 0.019) were significantly lower in hypertensive patients with ApHCM than in hypertensive patients without ApHCM. Among systolic parameters, the global longitudinal strain was independently associated with hypertension with ApHCM (odds ratio, 1.457; 95% confidence interval, 1.002–2.119; p = 0.049).ConclusionsReduced apical longitudinal and radial strains without a base-to-apex gradient were present in hypertensive patients with ApHCM. The global longitudinal strain was independently associated with ApHCM in hypertensive patients.

【 授权许可】

Unknown   
© Kao et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.