Reduced prevalence of placental malaria in primiparae with blood group O

Malaria Journal

Research

Kumarasamy Thangaraj¹  George Bedu-Addo²  Teunis A Eggelte³  Prabhanjan P Gai⁴  Stefanie Meese⁴  Frank P Mockenhaupt⁴ 

[1] Centre for Cellular and Molecular Biology, Hyderabad, India;Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, Amsterdam, The Netherlands;Institute of Tropical Medicine and International Health, Charité – University Medicine Berlin, Berlin, Germany;

关键词: Malaria;    Blood Group;    Severe Malaria;    Falciparum Infection;    Pyrimethamine;   

DOI  :  10.1186/1475-2875-13-289

 received in 2014-06-17, accepted in 2014-07-21,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundBlood group O protects African children against severe malaria and has reached high prevalence in malarious regions. However, its role in malaria in pregnancy is ambiguous. In 839 delivering Ghanaian women, associations of ABO blood groups with Plasmodium falciparum infection were examined.MethodsPlasmodium falciparum infection was diagnosed in placental blood samples by microscopy and PCR assays. Present or past infection was defined as the detection of parasitaemia or haemozoin by microscopy, or a positive PCR result. Blood groups were inferred from genotyping rs8176719 (indicating the O allele) and rs8176746/rs8176747 (distinguishing the B allele from the A allele).ResultsThe majority of women had blood group O (55.4%); present or past P. falciparum infection was seen in 62.3% of all women. Among multiparae, the blood groups had no influence on P. falciparum infection. In contrast, primiparae with blood group O had significantly less present or past infection than women with non-O blood groups (61.5 vs 76.2%, P = 0.007). In multivariate analysis, the odds of present or past placental P. falciparum infection were reduced by 45% in blood group O primiparae (aOR, 0.55 [95% CI, 0.33–0.94]).ConclusionsThe present study shows a clear protective effect of blood group O against malaria in primiparae. This accords with findings in severe malaria and in vitro results. The data underline the relevance of host genetic protection among primiparae, i.e. the high-risk group for malaria in pregnancy, and contribute to the understanding of high O allele frequencies in Africa.

【 授权许可】

Unknown   
© Bedu-Addo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.