Surgical management and outcome of spinal alveolar soft part sarcoma (ASPA): a case series of five patients and literature review

World Journal of Surgical Oncology

Research

Xin Gao¹  Wangjun Yan¹  Chenglong Zhao¹  Tao Tan¹  Xiaopan Cai¹  Jianru Xiao¹  Tielong Liu¹  Zhenxi Li¹  Cheng Yang¹  Jian Yang¹  Xinghai Yang¹  Tianhui Hou² 

[1] Spine Tumor Center, Department of orthopedic oncology, Changzheng Hospital, Second Military Medical University, Huangpu District, Fengyang Rd 415#, Shanghai, China;Spine Tumor Center, Department of orthopedic oncology, Changzheng Hospital, Second Military Medical University, Huangpu District, Fengyang Rd 415#, Shanghai, China;College of Physical Education and Health, East China Normal University, Minhang District, Dongchuan Rd 500#, Shanghai, China;

关键词: Spine;    ASPS;    Surgical management;    Prognostic factors;   

DOI  :  10.1186/s12957-017-1112-9

 received in 2016-07-16, accepted in 2017-02-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAlveolar soft part sarcoma (ASPS) is a rare entity of soft tissue malignancies with uncommon spinal involvements. Surgical management should be the best choice of cure.MethodsFive patients with spinal ASPS were interviewed retrospectively, where data was collected. The relevant literatures were also systematically examined. Thereafter, patient and surgical data were obtained and pooled for prognostic analysis.ResultsA total of five patients with eight surgeries were reviewed retrospectively, and three patients previously reported were also included. All patients were surgically treated, where five of them underwent additional adjuvant therapies such as chemotherapy, radiotherapy, and targeted therapy in order to manage their local and/or systematic diseases. One patient was lost in follow-up. For the remaining seven patients, the mean follow-up period was 19.7 ± 8.8 months, two succumbed to disease while five were alive at the time of the study.ConclusionsSurgical management is shown to be the most important and the most effective treatment strategy for spinal ASPS, whereas adjuvant therapies made little impact. The prognostic factors for spinal ASPS are primary or metastatic lesions, neurological status, disease progression, systematic conditions, and resection approaches.

【 授权许可】

CC BY   
© The Author(s). 2017