Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia

BMC Infectious Diseases

Research Article

Guangbo Zhang¹  Wujun Jiang²  Canhong Zhu²  Xinxing Zhang²  Wei Ji²  Yongdong Yan²  Huiming Sun²  Yuqing Wang²  Zhengrong Chen²  Xin Zhao³ 

[1] Clinical Immunology Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China;Department of Respiratory Disease, Children’s Hospital of Soochow University, Soochow University, Suzhou, China;General surgery department, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China;

关键词: Mycoplasma pneumoniae;    B7-H3;    Interleukin 36;    Children;    Bronchoalveolar lavage fluid;   

DOI  :  10.1186/s12879-016-1555-6

 received in 2015-11-20, accepted in 2016-05-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study is to explore the correlations of interleukin 36 (IL-36) and Soluble B7-H3 (sB7-H3) levels in bronchoalveolar lavage fluid (BALF) with clinical characteristics and laboratory findings.MethodsA total of 35 children with M. pneumnoiae pneumonia (MPP) and 15 control subjects were enrolled. BALF concentrations of sB7-H3 and IL-36 were detected using enzyme-linked immunosorbent assays and clinical profiles of children with MPP were obtained.ResultsChildren with MPP had significantly higher levels of sB7-H3 and IL-36 compared to control subjects (both P < 0.05). Meanwhile, children with pleural effusion had significantly higher levels of sB7-H3 and IL-36 compared to children without pleural effusion (both P < 0.05). BALF concentration of sB7-H3 was strongly associated with concentration of IL-36 (r = 0.796, P < 0.0001) and sB7-H3 was correlated with duration of fever (r = 0.427, P = 0.11) and length of stay (r = 0.345, P = 0.043). Both concentrations of sB7-H3 and IL-36 were significantly decreased in convalescent phase after treatment (both P < 0.05).ConclusionBoth soluble B7-H3 and IL-36 may play an important role in pathogenesis of M. pneumoniae infection and sB7-H3 could be useful as a prognostic predictor or biomarker of MPP.

【 授权许可】

CC BY   
© Chen et al. 2016