Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease

Cardiovascular Diabetology

Original Investigation

Bo Zerahn¹  Camilla N Rathcke²  Stine B Thomsen²  Henrik Vestergaard³ 

[1] Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Herlev, Denmark;Department of Medicine O, Center of Endocrinology and Metabolism, Copenhagen University Hospital Herlev, Denmark;Department of Medicine O, Center of Endocrinology and Metabolism, Copenhagen University Hospital Herlev, Denmark;Faculty of Health Sciences, University of Copenhagen, Denmark;

关键词: Ischemic Heart Disease;    Vascular Calcification;    Intima Calcification;    Coronary Artery Disease Group;    Calcification Process;   

DOI  :  10.1186/1475-2840-9-86

 received in 2010-11-03, accepted in 2010-12-08,  发布年份 2010

来源: Springer

【 摘 要 】

Objective and designLow grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcification of arteries, is increased in patients with atherosclerosis. In the present study levels of markers of calcification (MGP) and inflammation (YKL-40, hsCRP) were evaluated in patients with T2 D and/or ischemic heart disease (IHD).Materials and methodsThe study population consisted of 1) patients with T2D (n = 45); 2) patients with IHD (n = 37); patients with both T2D and IHD (n = 20) and 4) healthy controls (n = 20). Biochemical parameters were measured in venous blood samples.ResultsLevels of MGP, YKL-40 and hsCRP were increased in patients with IHD and/or T2D (p < 0.0001) and patients with T2D and IHD had higher MGP levels (p < 0.001). In multiple linear regression analyses MGP was associated with patient category (r = 0.36, p < 0.001), and HDL-cholesterol levels (r = 0.29, p < 0.001) adjusting for the significant covariates.ConclusionsIn patients with T2D and/or IHD we found increased levels of plasma MGP indicative of a progressing calcification process. This process is paralleled by increased levels of YKL-40 and hsCRP, which most likely reflect the concomitant low grade inflammatory state in these patients

【 授权许可】

Unknown   
© Thomsen et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.