Small dense LDL particles - a predictor of coronary artery disease evaluated by invasive and CT-based techniques: a case-control study

Lipids in Health and Disease

Research

Klaus Rasmussen¹  Annette Andreasen¹  Hans H Tilsted¹  Inge V Aardestrup¹  Anne P Toft-Petersen¹  Erik B Schmidt¹  Jens Aarøe¹  Thorkil Christensen²  Bruce A Griffin³ 

[1] Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark;Department of Radiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark;Faculty of Health & Medical Sciences, University of Surrey, GU2 7XH, Guildford, Surrey, UK;

关键词: Coronary Artery Disease;    Coronary Artery Disease Patient;    Iodixanol;    Coronary Artery Disease Group;    Significant Stenos;   

DOI  :  10.1186/1476-511X-10-21

 received in 2010-12-01, accepted in 2011-01-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCoronary angiography is the current standard method to evaluate coronary atherosclerosis in patients with suspected angina pectoris, but non-invasive CT scanning of the coronaries are increasingly used for the same purpose.Low-density lipoprotein (LDL) cholesterol and other lipid and lipoprotein variables are major risk factors for coronary artery disease. Small dense LDL particles may be of particular importance, but clinical studies evaluating their predictive value for coronary atherosclerosis are few.MethodsWe performed a study of 194 consecutive patients with chest pain, a priori considered of low to intermediate risk for significant coronary stenosis (>50% lumen obstruction) who were referred for elective coronary angiography. Plasma lipids and lipoproteins were measured including the subtype pattern of LDL particles, and all patients were examined by coronary CT scanning before coronary angiography.ResultsThe proportion of small dense LDL was a strong univariate predictor of significant coronary artery stenosis evaluated by both methods. After adjustment for age, gender, smoking, and waist circumference only results obtained by traditional coronary angiography remained statistically significant.ConclusionSmall dense LDL particles may add to risk stratification of patients with suspected angina pectoris.

【 授权许可】

Unknown   
© Toft-Petersen et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.