Effect of the rs2259816 polymorphism in the HNF1A gene on circulating levels of c-reactive protein and coronary artery disease (the ludwigshafen risk and cardiovascular health study)

BMC Medical Genetics

Research Article

Wilfried Renner¹  Marcus E Kleber²  Tanja B Grammer³  Winfried März⁴ 

[1] Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria;LURIC Study nonprofit LLC, Freiburg, Germany;Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany;Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany;Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany;

关键词: Coronary Artery Disease;    Rs2259816 Polymorphism;    Coronary Artery Disease Patient;    Rs2259816 Genotype;    Hepatocyte Nuclear Factor;   

DOI  :  10.1186/1471-2350-11-157

 received in 2010-05-11, accepted in 2010-11-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundC-reactive protein is a well established marker of inflammation and has been used to predict future cardiovascular disease. It is still controversial if it plays an active role in the development of cardiovascular disease. Recently, polymorphisms in the gene for HNF1α have been linked to the levels of C-reactive protein and coronary artery disease.MethodsWe investigated the association of the rs2259816 polymorphism in the HNF1A gene with the circulating level of C-reactive protein and the hazard of coronary artery disease in the LURIC Study cohort.ResultsCompared to CC homozygotes, the level of C-reactive protein was decreased in carriers of at least one A-allele. Each A-allele decreased CRP by approximately 15%. The odds ratio for coronary artery disease was only very slightly increased in carriers of the A-allele and this association did not reach statistical significance.ConclusionsIn the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease.

【 授权许可】

Unknown   
© Kleber et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.