IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients

BMC Immunology

Research Article

Paul Schnitzler¹  Arianeb Mehrabi²  Mahmoud Sadeghi³  Martin Zeier⁴  Imad Lahdou⁵  Volker Daniel⁵  Gerhard Opelz⁵ 

[1] Center for Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany;Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D-69120, Heidelberg, Germany;Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D-69120, Heidelberg, Germany;Transplantation Immunology, University of Heidelberg, Heidelberg, Germany;Department of Nephrology, University of Heidelberg, Heidelberg, Germany;Transplantation Immunology, University of Heidelberg, Heidelberg, Germany;

关键词: Kidney transplantation;    CMV;    IL-23;    Th17;    CMV-IgG;   

DOI  :  10.1186/s12865-016-0175-7

 received in 2016-05-11, accepted in 2016-09-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCytomegalovirus seropositivity is an independent risk factor for atherosclerosis in patients with ESRD. Donor CMV seropositivity is associated with higher graft loss. Dendritic cells, macrophages and Th17 lymphocytes are defined as producers of IL-23. IL-23 is thought to be involved in the promotion of Th17 cell polarization. Latent CMV-induced Th17 might be involved in the pathogenesis of CMV infection in patients with ESRD. We aimed to evaluate associations of Th17-dependent cytokines with ESRD, CMV status and post-transplant outcome in kidney transplantation.ResultsIL-21 plasma levels were similar in patients and healthy controls (p = 0.47), whereas IL-9 (p = 0.02) and IL-23 (p < 0.0001) levels were significantly higher in ESRD patients. CMV-seronegative (p = 0.002) and –seropositive (p < 0.001) patients had significantly higher IL-23 plasma levels than controls. CMV-seropositive patients showed excessively higher IL-23 (p < 0.001) plasma levels than CMV-seronegative patients. Patients with post-transplant CMV reactivation had higher IL-23 plasma levels than patients without CMV reactivation (p = 0.025).ConclusionsOur results indicate that latent CMV induces IL-23. IL-23 might be an inflammatory mediator of latent CMV infection in patients with ESRD and predisposes patients for post-transplant CMV reactivation.

【 授权许可】

CC BY   
© The Author(s). 2016