The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

Malaria Journal

Case Report

Frédéric Charlotte¹  Eric Farfour²  Pierre Buffet³  Catherine Settegrana⁴  Makoto Miyara⁵ 

[1] Laboratoire d'anatomie-pathologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France;Laboratoire de parasitologie-mycologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13, France;Unité Prévention et Thérapie Moléculaire des Maladies Humaines, CNR des corynébactéries du complexe diphtheriae, Institut Pasteur, 25-28 rue du Dr Roux, 75014, Paris, France;Laboratoire de parasitologie-mycologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13, France;Unité d'Immunologie Moléculaire des Parasites, Institut Pasteur, Paris, France;Inserm-UPMC, Paris 6 Université, UMRs945, 91 boulevard de l’hôpital, 75013, Paris, France;Laboratoire d’hématologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France;Service de médecine interne 2, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France;Département d’immunologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France;

关键词: Malaria;    Transmission;    Gametocyte;    Bone marrow;    Plasmodium falciparum;   

DOI  :  10.1186/1475-2875-11-285

 received in 2012-06-05, accepted in 2012-07-31,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPlasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.MethodsThe stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.ResultsA majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.Discussion and conclusionThese observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.

【 授权许可】

Unknown   
© Farfour et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.