Cardiovascular Diabetology | |
Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people | |
Original Investigation | |
Shen Qu1  Zhen Yang1  Weiwei Zhang2  Zi Ye3  Xiaoming Tao3  Jie Wen3  Qin Li3  Xuanchun Wang3  Renming Hu3  Ying Huang3  Lili Chen3  Zhaoyun Zhang3  Bin Lu3  Min He3  | |
[1] Department of Endocrinology, Shanghai tenth people's hospital, School of medicine, Tongji University, Shanghai, China;Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China;Institute of Endocrinology and Diabetology, Huashan hospital, Shanghai Medical College, Fudan University, Shanghai, China; | |
关键词: Lipocalin-2; Impaired glucose regulation; Type 2 diabetes; Insulin resistance; | |
DOI : 10.1186/1475-2840-11-11 | |
received in 2011-11-07, accepted in 2012-01-31, 发布年份 2012 | |
来源: Springer | |
【 摘 要 】
BackgroundLipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a large-scale Chinese population.MethodsWe evaluated serum lipocalin-2 in a cross-sectional sample of 2519 Chinese aged from 50 to 82 year in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured.ResultsSerum lipocalin-2 was significantly higher in subjects with isolated impaired fasting glucose, isolated impaired glucose tolerance, combined impaired fasting glucose/impaired glucose tolerance and newly-diagnosed type 2 diabetes than in those with normal glucose regulation. Lipocalin-2 elevation was clearly associated with a higher risk for impaired glucose regulation (OR 1.30 for each 10 ng/ml increase in serum lipocalin-2, 95% CI 1.23-1.62, p = 0.009) after adjustment of age, gender, smoking, alcohol drinking, family history of diabetes, serum CRP, serum adiponectin, serum CXCL5, HOMA-IR, BMI, and waist/hip ratio. The OR for participants with impaired glucose regulation and type 2 diabetes was 1.31 (95% CI 1.21-1.69, p < 0.001).ConclusionsOur findings suggest that elevated serum lipocalin-2 is closely and independently associated with impaired glucose regulation and type 2 diabetes.
【 授权许可】
CC BY
© Huang et al; licensee BioMed Central Ltd. 2012
【 预 览 】
Files | Size | Format | View |
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RO202311103071321ZK.pdf | 556KB | download |
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