Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people

Cardiovascular Diabetology

Original Investigation

Shen Qu¹  Zhen Yang¹  Weiwei Zhang²  Zi Ye³  Xiaoming Tao³  Jie Wen³  Qin Li³  Xuanchun Wang³  Renming Hu³  Ying Huang³  Lili Chen³  Zhaoyun Zhang³  Bin Lu³  Min He³ 

[1] Department of Endocrinology, Shanghai tenth people's hospital, School of medicine, Tongji University, Shanghai, China;Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China;Institute of Endocrinology and Diabetology, Huashan hospital, Shanghai Medical College, Fudan University, Shanghai, China;

关键词: Lipocalin-2;    Impaired glucose regulation;    Type 2 diabetes;    Insulin resistance;   

DOI  :  10.1186/1475-2840-11-11

 received in 2011-11-07, accepted in 2012-01-31,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundLipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a large-scale Chinese population.MethodsWe evaluated serum lipocalin-2 in a cross-sectional sample of 2519 Chinese aged from 50 to 82 year in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured.ResultsSerum lipocalin-2 was significantly higher in subjects with isolated impaired fasting glucose, isolated impaired glucose tolerance, combined impaired fasting glucose/impaired glucose tolerance and newly-diagnosed type 2 diabetes than in those with normal glucose regulation. Lipocalin-2 elevation was clearly associated with a higher risk for impaired glucose regulation (OR 1.30 for each 10 ng/ml increase in serum lipocalin-2, 95% CI 1.23-1.62, p = 0.009) after adjustment of age, gender, smoking, alcohol drinking, family history of diabetes, serum CRP, serum adiponectin, serum CXCL5, HOMA-IR, BMI, and waist/hip ratio. The OR for participants with impaired glucose regulation and type 2 diabetes was 1.31 (95% CI 1.21-1.69, p < 0.001).ConclusionsOur findings suggest that elevated serum lipocalin-2 is closely and independently associated with impaired glucose regulation and type 2 diabetes.

【 授权许可】

CC BY   
© Huang et al; licensee BioMed Central Ltd. 2012